Analysis Tools
mortality/aging
|
• no homozygous mutant mice are born from heterozygous intercrosses
|
|
Allele Symbol Allele Name Allele ID |
Wdr3tm1a(KOMP)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4362309 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no homozygous mutant mice are born from heterozygous intercrosses
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• adult mice show normal placing behavior in a visual placing response test, and exhibit no changes in the time spent in the central area of the open field suggesting normal anxiety levels
|
|
|
• in the open field test, adult male mice show a slight but significant increase in total distance traveled and in distance traveled per minute along with a significant reduction in the % of resting time, suggesting increased spontaneous locomotor activity
• walking speed remains unaffected
|
|
N |
• male mice show normal developmental weight gain and no differences in body weight at 10 weeks of age relative to age-matched wild-type controls
|
|
N |
• adult brain anatomy is grossly normal with no detectable changes in hippocampus and cerebral cortex histology
• Real-time PCR analysis showed normal expression levels of 18S rRNA in the cerebral cortex, hippocampus and cerebellum
|
|
N |
• adult mice exhibit normal visual function in a visual placing response test
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/14/2024 MGI 6.23 |
|
|
|
||