Phenotypes associated with this allele

• Allele Symbol: Alox8^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362187
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alox8^tm1a(KOMP)Wtsi/Alox8^tm1a(KOMP)Wtsi	C57BL/6N-Alox8^tm1a(KOMP)Wtsi/MbpMmucd	MGI:6359791

Genotype
MGI:6359791

hm1

• Allelic Composition: Alox8^{tm1a(KOMP)Wtsi}/Alox8^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Alox8^{tm1a(KOMP)Wtsi}/MbpMmucd
• Cell Lines: EPD0094_1_D04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased interleukin-6 secretion ( J:277623 )

• in the lungs of influenza-infected mice

lung inflammation ( J:277623 )

• increased following influenza virus

abnormal susceptibility to Orthomyxoviridae infection ( J:277623 )

• influenza-infected mice exhibit impaired recovery with extended period of reduced body temperature, reduced locomotor activity and reduced body weight with increased residual viral RNA and increased lung inflammation and necrosis compared with wild-type mice

respiratory system

pulmonary necrosis ( J:277623 )

• increased following influenza virus

lung inflammation ( J:277623 )

• increased following influenza virus

growth/size/body

decreased body weight ( J:277623 )

• following influenza virus for longer than in wild-type mice

homeostasis/metabolism

decreased body temperature ( J:277623 )

• following influenza virus for the duration of the post-inoculation period unlike wild-type mice which only exhibit reduced temperature for 2 days

behavior/neurological

decreased locomotor activity ( J:277623 )

• following influenza virus for longer than in wild-type mice

cellular

pulmonary necrosis ( J:277623 )

• increased following influenza virus