Analysis Tools
homeostasis/metabolism
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• at 16 weeks, mice fed a high-fat diet exhibit reduced glucose-stimulated insulin release compared with similarly treated wild-type mice
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• at 10 weeks, mice fed a high-fat diet exhibit a 10% increase in weight gain compared with similarly treated wild-type mice
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• at 25 weeks, female mice fed a high-fat diet exhibit an increased in plasma glucose level compared with similarly treated wild-type mice
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• at 10 weeks, mice exhibit mild glucose intolerance compared with similarly treated wild-type mice
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• pancreatic islets lack zinc unlike in wild-type mice
• beta cells exhibit no zinc exocytotic events unlike wild-type cells
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endocrine/exocrine glands
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• secretory vessels lack the normal condensed aspect unlike in wild-type cells
• however, mice exhibit normal insulin processing, glucose-induced insulin release, and calcium changes in beta cells
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• at 16 weeks, mice fed a high-fat diet exhibit reduced glucose-stimulated insulin release compared with similarly treated wild-type mice
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growth/size/body
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• at 10 weeks, mice fed a high-fat diet exhibit a 10% increase in weight gain compared with similarly treated wild-type mice
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