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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pstpip1tm1Spg
targeted mutation 1, Stephen P Goff
MGI:4361584
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pstpip1tm1Spg/Pstpip1tm1Spg involves: 129S/SvEv * C57BL/6 MGI:5298078


Genotype
MGI:5298078
hm1
Allelic
Composition		 Pstpip1tm1Spg/Pstpip1tm1Spg
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pstpip1tm1Spg mutation (3 available); any Pstpip1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:101977 )
• T cells are hyperresponsive to antigen receptor stimulation
abnormal immune system cell morphology ( J:101977 )
• mice exhibit various defects in immune cells

hematopoietic system
abnormal T cell physiology ( J:101977 )
• T cells are hyperresponsive to antigen receptor stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory