Phenotypes associated with this allele

• Allele Symbol: Tg(Col1a1-Atf4)1Kry
• Allele Name: transgene insertion 1, Gerard Karsenty
• Allele ID: MGI:4360488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Col1a1-Atf4)1Kry/0	involves: FVB	MGI:4360505

Genotype
MGI:4360505

tg1

• Allelic Composition: Tg(Col1a1-Atf4)1Kry/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in islet insulin content in Tg(Col1a1-Atf4)1Kry/0 pancreas

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:152695 )

N • serum leptin, resistin, and adiponectin levels are normal

decreased insulin secretion ( J:152695 )

• following glucose challenge, insulin secretion is decreased compared to in wild-type mice

• islet insulin content is decreased compared to in wild-type mice

abnormal circulating glucose level ( J:152695 )

• treatment with warfarin decreases blood glucose more than in wild-type mice

increased circulating glucose level ( J:152695 )

• mice exhibit an increase in serum glucose levels compared with wild-type mice

• however, treatment with osteocalcin restores serum glucose levels to normal

decreased circulating insulin level ( J:152695 )

• mice exhibit a decrease in serum insulin levels compared with wild-type mice

• however, treatment with osteocalcin restores serum insulin levels to normal

impaired glucose tolerance ( J:152695 )

• mice exhibit impaired glucose tolerance compared with wild-type mice

• however, treatment with osteocalcin restores normal glucose tolerance

increased physiological sensitivity to xenobiotic ( J:152695 )

• treatment with warfarin decreases blood glucose more than in wild-type mice

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is decreased compared to in wild-type mice

decreased insulin secretion ( J:152695 )

• following glucose challenge, insulin secretion is decreased compared to in wild-type mice

• islet insulin content is decreased compared to in wild-type mice

cellular

decreased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is decreased compared to in wild-type mice