Analysis Tools
mortality/aging
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• between 2 and 20 weeks, mortality is greater than in wild-type mice
• over 40% of mice are dead by 20 weeks of age whereas all wild-type mice remain alive
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• between 2 and 20 weeks, mortality is greater than in wild-type mice
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cardiovascular system
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• at 20 weeks, mice exhibit advanced chronic hepatic congestion unlike in wild-type mice
• mice exhibit liver with areas of central venous congestion unlike in wild-type mice
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• mice exhibit heterogeneity in myocyte size with some vacuolization unlike in wild-type mice
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• left ventricular end systolic and end diastolic dimensions are increased 33% and 18%, respectively, compared to in wild-type mice
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• mice exhibit biventricular enlargement without an increase in wall thickness or increase in ventricular weight
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• as early as 4 weeks, mice exhibit dilated cardiomyopathy in all four chambers of the heart unlike wild-type mice
• by 8 weeks, all mice exhibit dilated cardiomyopathy without inflammatory cell infiltration
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• treatment with isoproterenol induces less of an increase in fractional shortening compared to in similarly treated wild-type mice
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• left ventricular shortening fraction is decreased 35% compared to in wild-type mice
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• treatment with isoproterenol exhibit reduced left ventricle diastolic and systolic pressure response compared with similarly treated wild-type mice
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• 35% less than in wild-type mice
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• 24% less than in wild-type mice
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• some myocytes exhibit hypertrophy while others exhibit atrophy
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homeostasis/metabolism
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• atrial and ventricular
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• between 8 and 20 weeks, mice exhibit severe peripheral edema unlike wild-type mice
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• treatment with isoproterenol induces less of an increase in fractional shortening compared to in similarly treated wild-type mice
• treatment with isoproterenol exhibit reduced left ventricle diastolic and systolic pressure response compared with similarly treated wild-type mice
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liver/biliary system
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• at 20 weeks, livers have a nutmeg appearance with dark red areas of central venous congestion and central lobular necrosis unlike in wild-type mice
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• at 20 weeks, mice exhibit advanced chronic hepatic congestion unlike in wild-type mice
• mice exhibit liver with areas of central venous congestion unlike in wild-type mice
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• at 20 weeks, mice exhibit central lobular necrosis unlike wild-type mice
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respiratory system
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• between 8 and 20 weeks
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behavior/neurological
muscle
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• mice exhibit heterogeneity in myocyte size with some vacuolization unlike in wild-type mice
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• as early as 4 weeks, mice exhibit dilated cardiomyopathy in all four chambers of the heart unlike wild-type mice
• by 8 weeks, all mice exhibit dilated cardiomyopathy without inflammatory cell infiltration
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• treatment with isoproterenol induces less of an increase in fractional shortening compared to in similarly treated wild-type mice
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• left ventricular shortening fraction is decreased 35% compared to in wild-type mice
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growth/size/body
cellular
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• at 20 weeks, mice exhibit central lobular necrosis unlike wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:133881 | |
