Phenotypes associated with this allele

• Allele Symbol: Atp1b1^tm1.1Akra
• Allele Name: targeted mutation 1.1, Ayyappan K Rajasekaran
• Allele ID: MGI:4360184
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp1b1^tm1.1Akra/Atp1b1^tm1.1Akra	involves: 129S/SvEv	MGI:4360205
cn2	Atp1b1^tm1.1Akra/Atp1b1^tm1.1Akra Myl2^tm1(cre)Krc/Myl2^+	involves: 129S/SvEv * 129S4/SvJae	MGI:4360206

Genotype
MGI:4360205

hm1

• Allelic Composition: Atp1b1^tm1.1Akra/Atp1b1^tm1.1Akra
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:152596 )

• mice are distinguishable from wild-type mice

Genotype
MGI:4360206

cn2

• Allelic Composition: Atp1b1^tm1.1Akra/Atp1b1^tm1.1Akra; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:152596 )

• following transverse aortic constriction, mice exhibit increased mortality compared to wild-type mice

cardiovascular system

increased heart weight ( J:152596 )

• at post-mortem

cardiac hypertrophy ( J:152596 )

• at 13 to 14 months

abnormal cardiac muscle contractility ( J:152596 )

• maximum rate of heart contraction and relaxation is increased compared to in wild-type mice

decreased ventricle muscle contractility ( J:152596 )

• at 13 to 14 months, mice exhibit decreased fractional shortening, velocity of circumferential fiber shortening, and ejection fraction compared with wild-type mice

• following transverse aortic constriction, mice exhibit decreased fractional shortening, velocity of circumferential fiber shortening, and ejection fraction compared with wild-type mice

• mice treated with ouabain fail to exhibit an increase in maximum rate of heart contraction and relaxation unlike similarly treated wild-type mice

abnormal myocardial fiber physiology ( J:152596 )

• the amplitude of calcium ion released from cardiomyocyte is increased 1.6-fold compared to in wild-type cells

• time to peak calcium ion release from cardiomyocyte is increased compared to in wild-type cells

increased response of heart to induced stress ( J:152596 )

• following transverse aortic constriction, mice exhibit signs of heart dysfunction, decreased ventricular function, and increased mortality compared to wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:152596 )

• following transverse aortic constriction, mice exhibit signs of heart dysfunction, decreased ventricular function, and increased mortality compared to wild-type mice

decreased physiological sensitivity to xenobiotic ( J:152596 )

• mice treated with ouabain fail to exhibit an increase in maximum rate of heart contraction and relaxation unlike similarly treated wild-type mice

• cardiomyocytes treated with ouabain fail to exhibit alterations in calcium ion transients unlike similarly treated wild-type cells

muscle

abnormal cardiac muscle contractility ( J:152596 )

• maximum rate of heart contraction and relaxation is increased compared to in wild-type mice

decreased ventricle muscle contractility ( J:152596 )

• at 13 to 14 months, mice exhibit decreased fractional shortening, velocity of circumferential fiber shortening, and ejection fraction compared with wild-type mice

• following transverse aortic constriction, mice exhibit decreased fractional shortening, velocity of circumferential fiber shortening, and ejection fraction compared with wild-type mice

• mice treated with ouabain fail to exhibit an increase in maximum rate of heart contraction and relaxation unlike similarly treated wild-type mice

growth/size/body

increased heart weight ( J:152596 )

• at post-mortem

cardiac hypertrophy ( J:152596 )

• at 13 to 14 months