Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Mir208a)#Dzw
• Allele Name: transgene insertion #, Da-Zhi Wnag
• Allele ID: MGI:4359827
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tarbp2^tm1.1Dzw/Tarbp2^tm1.1Dzw Tg(tetO-Mir208a)#Dzw/? Tg(Tnnt2-cre)5Blh/?	involves: 129 * C3H * C57BL/6 * DBA/2J	MGI:5645730
cx2	Tg(Myh6-tTA)6Smbf/0 Tg(tetO-Mir208a)#Dzw/0	involves: C3H * C57BL/6 * CBA	MGI:4359864

Genotype
MGI:5645730

cn1

• Allelic Composition: Tarbp2^tm1.1Dzw/Tarbp2^tm1.1Dzw; Tg(tetO-Mir208a)#Dzw/?; Tg(Tnnt2-cre)5Blh/?
• Genetic Background: involves: 129 * C3H * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:222613 )

N • transgenic expression of Mir208a prevents the onset of dilated cardiomyopathy in cardiac conditional knockouts of Tarbp2 and results in mice with normal heart morphology, histology, and function

Genotype
MGI:4359864

cx2

• Allelic Composition: Tg(Myh6-tTA)6Smbf/0; Tg(tetO-Mir208a)#Dzw/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

Enlarged heart in Tg(tetO-Mir208a)#Dzw/0 Tg(Myh6-tTA)6Smbf/0 mice

cardiovascular system

abnormal myocardial fiber morphology ( J:152696 )

• cardiomyocytes are about 50% bigger than in controls

enlarged heart ( J:152696 )

• a dramatic increase in size is seen at 4 months of age

increased heart weight ( J:152696 )

• heart weight to body weight ratios are increased

cardiac hypertrophy ( J:152696 )

• chambers are enlarged and ventricle walls are thickened suggesting hypertrophic growth

abnormal heart left ventricle morphology ( J:152696 )

• left ventricle diameter is increased in diastole and systole

thick ventricular wall ( J:152696 )

cardiac interstitial fibrosis ( J:152696 )

decreased cardiac muscle contractility ( J:152696 )

• a decrease in fractional shortening is detected at 3 and 7 months of age

atrioventricular block ( J:152696 )

• about 30% of mice show second degree AV blocks, in which one or more of the electrical impulses from the atria failed to pass through the AV node to the ventricles

prolonged PR interval ( J:152696 )

• at 7 months of age, prolongation of the PR interval is seen indicating a first degree atrioventricular (AV) block

muscle

abnormal myocardial fiber morphology ( J:152696 )

• cardiomyocytes are about 50% bigger than in controls

decreased cardiac muscle contractility ( J:152696 )

• a decrease in fractional shortening is detected at 3 and 7 months of age

growth/size/body

enlarged heart ( J:152696 )

• a dramatic increase in size is seen at 4 months of age

increased heart weight ( J:152696 )

• heart weight to body weight ratios are increased

cardiac hypertrophy ( J:152696 )

• chambers are enlarged and ventricle walls are thickened suggesting hypertrophic growth

cellular

cardiac interstitial fibrosis ( J:152696 )