Phenotypes associated with this allele

• Allele Symbol: Camk2b^tm1Yelg
• Allele Name: targeted mutation 1, Ype Elgersma
• Allele ID: MGI:4359775
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2b^tm1Yelg/Camk2b^tm1Yelg	involves: 129P2/OlaHsd	MGI:5285584
hm2	Camk2b^tm1Yelg/Camk2b^tm1Yelg	involves: 129P2/OlaHsd * C57BL/6	MGI:4359783

Genotype
MGI:5285584

hm1

• Allelic Composition: Camk2b^tm1Yelg/Camk2b^tm1Yelg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:174521 )

N • gross neuronal development is normal

reduced long-term potentiation ( J:174521 )

behavior/neurological

impaired contextual conditioning behavior ( J:174521 )

• in the 24 h long-term memory test

Genotype
MGI:4359783

hm2

• Allelic Composition: Camk2b^tm1Yelg/Camk2b^tm1Yelg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

nervous system phenotype ( J:152575 )

N • brain development and Purkinje cell maturation are normal

abnormal synaptic plasticity ( J:152575 )

• direction of plasticity at parallel fiber-Purkinje cell synapses is reversed compared to in wild-type mice

abnormal long-term potentiation ( J:152575 )

• protocols designed to stimulate long term depression induce long term potentiation (LTP)

• however, treatment with KN93 restores normal LTP induction

• protocols designed to stimulate long term potentiation induce long term depression (LTD)

abnormal long-term depression ( J:152575 )

• protocols designed to stimulate long term potentiation induce long term depression (LTD)

• however, treatment with cyclosporin A restores normal LTD induction

• protocols designed to stimulate long term depression induce long term potentiation (LTP)

behavior/neurological

ataxia ( J:152575 )

• mice exhibit an ataxic gait unlike wild-type mice

impaired coordination ( J:152575 )

• on a rotarod and balance beam