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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grk5tm2Rjl
targeted mutation 2, Robert J Lefkowitz
MGI:4359730
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Grk5tm2Rjl/Grk5+ B6.129S4-Grk5tm2Rjl MGI:4359758
cn2
 		Grk5tm2Rjl/Grk5tm2Rjl
Tg(Myh6-cre)2182Mds/0 		involves: 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:5582621


Genotype
MGI:4359758
ht1
Allelic
Composition		 Grk5tm2Rjl/Grk5+
Genetic
Background		 B6.129S4-Grk5tm2Rjl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk5tm2Rjl mutation (1 available); any Grk5 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:152746 )
• mice are viable and fertile and show no obvious abnormal phenotype




Genotype
MGI:5582621
cn2
Allelic
Composition		 Grk5tm2Rjl/Grk5tm2Rjl
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk5tm2Rjl mutation (1 available); any Grk5 mutation (44 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy compared with wild-type mice
decreased response of heart to induced stress ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy with no increase in left ventricular dilatation and no change in ejection fraction compared with wild-type mice

homeostasis/metabolism
decreased response of heart to induced stress ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy with no increase in left ventricular dilatation and no change in ejection fraction compared with wild-type mice

growth/size/body
cardiac hypertrophy ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory