Phenotypes associated with this allele

• Allele Symbol: Mir143^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:4359259
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir143^tm1.1Eno/Mir143^tm1.1Eno	involves: 129S/SvEv * C57BL/6	MGI:4359266

Genotype
MGI:4359266

hm1

• Allelic Composition: Mir143^tm1.1Eno/Mir143^tm1.1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular wound healing ( J:152458 )

• following carotid artery ligation, mice exhibit a 60% reduction in neointimal thickening unlike similarly treated wild-type mice that is not as severe as in Mir145^tm1Eno or Mir145/Mir143^tm1.2Eno homozygotes

• following carotid artery ligation, medial layer thickness is reduced compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal vascular wound healing ( J:152458 )

• following carotid artery ligation, mice exhibit a 60% reduction in neointimal thickening unlike similarly treated wild-type mice that is not as severe as in Mir145^tm1Eno or Mir145/Mir143^tm1.2Eno homozygotes

• following carotid artery ligation, medial layer thickness is reduced compared to in similarly treated wild-type mice