Phenotypes associated with this allele

• Allele Symbol: Arx^tm3Kki
• Allele Name: targeted mutation 3, Kunio Kitamura
• Allele ID: MGI:4359176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Arx^tm3Kki/Y	involves: 129S/SvEv * C57BL/6J	MGI:4359206

Genotype
MGI:4359206

ot1

• Allelic Composition: Arx^tm3Kki/Y
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:152416 )

♂N • mice live for more than 6 months

increased susceptibility to induced morbidity/mortality ( J:152416 )

♂ • following administration of bicuculline

nervous system

increased susceptibility to pharmacologically induced seizures ( J:152416 )

♂ • following administration of bicuculline, mice exhibit quicker onset of seizures, greater incidence of generalized seizures, and increased mortality compared with similarly treated wild-type mice

abnormal neuronal migration ( J:152416 )

♂ • 93% of Arx+ GABAergic cells that migrate in wild-type mice reach the cortical plate by P0

♂ • at P0, tangential migration of SST+ GABAergic neurons is suppressed compared to in wild-type mice

loss of GABAergic neurons ( J:152416 )

♂ • slight in the cortex and striatum

abnormal cholinergic neuron morphology ( J:152416 )

♂ • at 1 month, cholinergic neurons in the striatum, medial septum, and ventral forebrain nuclei are reduced compared to in wild-type mice

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:152416 )

♂ • following administration of bicuculline, mice exhibit quicker onset of seizures, greater incidence of generalized seizures, and increased mortality compared with similarly treated wild-type mice

impaired passive avoidance behavior ( J:152416 )

♂ • compared to wild-type mice that is not as bad as in Arx^tm4Kki homozygotes

abnormal spatial learning ( J:152416 )

♂ • mice exhibit impaired spatial learning in a win-shift task on the 8-arm radial maze compared with wild-type mice that is not as severe as in Arx^tm4Kki homozygotes

increased anxiety-related response ( J:152416 )

♂

impaired coordination ( J:152416 )

♂

hyperactivity ( J:152416 )

♂

cellular

abnormal neuronal migration ( J:152416 )

♂ • 93% of Arx+ GABAergic cells that migrate in wild-type mice reach the cortical plate by P0

♂ • at P0, tangential migration of SST+ GABAergic neurons is suppressed compared to in wild-type mice