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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk4tm1.2Wtao
targeted mutation 1.2, Wufan Tao
MGI:4358205
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stk4tm1.2Wtao/Stk4tm1.2Wtao involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:4358231
cn2
 		Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J MGI:4358230


Genotype
MGI:4358231
hm1
Allelic
Composition		 Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4tm1.2Wtao mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte number ( J:152323 )
• mature single positive thymocytes
increased single-positive T cell number ( J:152323 )
• mature single positive thymocytes
decreased lymphocyte cell number ( J:152323 )
• in the axillary lymph nodes and Peyer's patches
decreased B cell number ( J:152323 )
• 76% in the blood
decreased CD4-positive, alpha-beta T cell number ( J:152323 )
• 86% in the blood and 45% in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:152323 )
• 88% in the blood and 26% in the spleen
abnormal T cell physiology ( J:152323 )
• in a competitive assay, the ratio of T cells to wild-type T cells is 1.5 to 1 in the blood and 1.2 to 1 in the spleen due to impaired homing to peripheral lymphoid organs while the ratio is 0.5 to 1 in the lymph node due to reduced emigration of T cells into the circulation after entry into the secondary lymph organs or nonlymphoid tissues
• emigration of mature thymocytes from the thymus into the spleen is reduced compared to emigration of wild-type cells
• however, mature T cells exhibit normal S1P-mediated transmigration across endothelial cells in vitro
• the number of mobilized thymocytes in response to CCL19 is lower than for wild-type cells
• single positive thymocytes exhibit reduced response to CXCL12 and CCL25 compared with wild-type cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:152323 )
• CD4+ T cells exhibit a lower response to CCL21a and CCL19 compared with wild-type cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:152323 )
• CD8+ T cells exhibit a hyper chemotactic response to S1P compared with wild-type cells
• CD8+ T cells exhibit a lower response to CCL21a compared with wild-type cells
• immature CD8+ T cells exhibit reduced response to CCR19 compared with wild-type cells

hematopoietic system
increased thymocyte number ( J:152323 )
• mature single positive thymocytes
increased single-positive T cell number ( J:152323 )
• mature single positive thymocytes
decreased lymphocyte cell number ( J:152323 )
• in the axillary lymph nodes and Peyer's patches
decreased B cell number ( J:152323 )
• 76% in the blood
decreased CD4-positive, alpha-beta T cell number ( J:152323 )
• 86% in the blood and 45% in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:152323 )
• 88% in the blood and 26% in the spleen
abnormal T cell physiology ( J:152323 )
• in a competitive assay, the ratio of T cells to wild-type T cells is 1.5 to 1 in the blood and 1.2 to 1 in the spleen due to impaired homing to peripheral lymphoid organs while the ratio is 0.5 to 1 in the lymph node due to reduced emigration of T cells into the circulation after entry into the secondary lymph organs or nonlymphoid tissues
• emigration of mature thymocytes from the thymus into the spleen is reduced compared to emigration of wild-type cells
• however, mature T cells exhibit normal S1P-mediated transmigration across endothelial cells in vitro
• the number of mobilized thymocytes in response to CCL19 is lower than for wild-type cells
• single positive thymocytes exhibit reduced response to CXCL12 and CCL25 compared with wild-type cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:152323 )
• CD4+ T cells exhibit a lower response to CCL21a and CCL19 compared with wild-type cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:152323 )
• CD8+ T cells exhibit a hyper chemotactic response to S1P compared with wild-type cells
• CD8+ T cells exhibit a lower response to CCL21a compared with wild-type cells
• immature CD8+ T cells exhibit reduced response to CCR19 compared with wild-type cells

endocrine/exocrine glands
increased thymocyte number ( J:152323 )
• mature single positive thymocytes




Genotype
MGI:4358230
cn2
Allelic
Composition		 Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4tm1.1Wtao mutation (0 available); any Stk4 mutation (72 available)
Stk4tm1.2Wtao mutation (0 available); any Stk4 mutation (72 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:152323 )
• peripheral T cells
decreased CD4-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes

hematopoietic system
decreased T cell number ( J:152323 )
• peripheral T cells
decreased CD4-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes

endocrine/exocrine glands




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory