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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Fadd)33Wnt
transgene insertion 33, Astar Winoto
MGI:4358105
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0
Tg(Lck-cre)I57Jxm/0
Tg(Tcra2C,Tcrb2C)1Dlo/0 		involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL MGI:4358109
cn2
 		Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0
Tg(Lck-cre)I57Jxm/0 		involves: 129S4/SvJae * C57BL/6 * CBA * ICR MGI:4358108
cx3
 		Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:4358107


Genotype
MGI:4358109
cn1
Allelic
Composition		 Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0
Tg(Lck-cre)I57Jxm/0
Tg(Tcra2C,Tcrb2C)1Dlo/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Wnt mutation (0 available); any Fadd mutation (19 available)
Tg(Fadd)33Wnt mutation (0 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
Tg(Tcra2C,Tcrb2C)1Dlo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:4358108
cn2
Allelic
Composition		 Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Wnt mutation (0 available); any Fadd mutation (19 available)
Tg(Fadd)33Wnt mutation (0 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:69617 )
• reduced 2-fold
abnormal T cell differentiation ( J:69617 )
• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice
decreased double-positive T cell number ( J:69617 )
• percent and absolute number
increased B cell number ( J:69617 )
• in the periphery
decreased CD4-positive, alpha-beta T cell number ( J:69617 )
• lower percentage in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:69617 )
• lower percentage in the periphery

hematopoietic system
thymus hypoplasia ( J:69617 )
• reduced 2-fold
abnormal T cell differentiation ( J:69617 )
• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice
decreased double-positive T cell number ( J:69617 )
• percent and absolute number
increased B cell number ( J:69617 )
• in the periphery
decreased CD4-positive, alpha-beta T cell number ( J:69617 )
• lower percentage in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:69617 )
• lower percentage in the periphery

endocrine/exocrine glands
thymus hypoplasia ( J:69617 )
• reduced 2-fold




Genotype
MGI:4358107
cx3
Allelic
Composition		 Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Wnt mutation (0 available); any Fadd mutation (19 available)
Tg(Fadd)33Wnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:69617 )
N
• mice exhibit normal T cell development and proliferation




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory