Phenotypes associated with this allele

• Allele Symbol: Klra17^tm1.1Apma
• Allele Name: targeted mutation 1.1, Andrew P Makrigiannis
• Allele ID: MGI:4357862
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klra17^tm1.1Apma/Klra17^tm1.1Apma	involves: 129S1/Sv * 129X1/SvJ	MGI:4357867

Genotype
MGI:4357867

hm1

• Allelic Composition: Klra17^tm1.1Apma/Klra17^tm1.1Apma
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased plasmacytoid dendritic cell number ( J:152288 )

• in mice older than 9 months, the proportion and total number of plasmacytoid dendritic cells is increased 2-fold compared to in wild-type mice

decreased circulating interferon-alpha level ( J:152288 )

• 5- to 10-fold in mice injected with CpG-oligonucleotide

decreased circulating interleukin-12 level ( J:152288 )

• 36 hours after MCMV infection, IL12p70 serum levels are slightly decreased compared to in similarly treated wild-type mice

abnormal plasmacytoid dendritic cell physiology ( J:152288 )

• plasmacytoid dendritic cell (pDC) exposed to mouse plasmacytoid dendritic cell antigen-1-conjugated magnetic beads produce 5-fold lower levels of IFN-alpha than similarly treated wild-type cells

• pDCs exhibit reduced IL12 secretion in response to CpG-oligonucleotide compared with similarly treated wild-type cells

• in response to influenza, pDCs produce 5-fold less IFN-alpha and 3-fold less IL12 than similarly treated wild-type cells

• in response to MCMV infection, pDCs produce 3-fold less IFN-alpha compared to in similarly treated wild-type cells

• however, pDC activation is normal

decreased interferon-alpha secretion ( J:152288 )

• plasmacytoid dendritic cell exposed to mouse plasmacytoid dendritic cell antigen-1-conjugated magnetic beads produce 5-fold lower levels of IFN-alpha than similarly treated wild-type cells

• in response to influenza, pDCs produce 5-fold less IFN-alpha and 3-fold less IL12 than similarly treated wild-type cells

• in response to MCMV infection, pDCs produce 3-fold less IFN-alpha compared to in similarly treated wild-type cells

decreased interleukin-12 secretion ( J:152288 )

• pDCs exhibit reduced IL12 secretion in response to CpG-oligonucleotide compared with similarly treated wild-type cells

• in response to influenza, pDCs produce 5-fold less IFN-alpha and 3-fold less IL12 than similarly treated wild-type cells

abnormal response to infection ( J:152288 )

• in response to influenza, pDCs produce 5-fold less IFN-alpha and 3-fold less IL12 than similarly treated wild-type cells

increased susceptibility to Herpesvirales infection ( J:152288 )

• in response to MCMV infection, pDCs produce 3-fold less IFN-alpha compared to in similarly treated wild-type cells

• mice infected with MCMV exhibit higher splenic titers than similarly treated wild-type mice

• 36 hours after MCMV infection, IL12p70 serum levels are slightly decreased compared to in similarly treated wild-type mice

• however, IFN-alpha serum levels 36 hours after infection with MCMV are normal

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:152288 )

• 5- to 10-fold in mice injected with CpG-oligonucleotide

decreased circulating interleukin-12 level ( J:152288 )

• 36 hours after MCMV infection, IL12p70 serum levels are slightly decreased compared to in similarly treated wild-type mice

hematopoietic system

increased plasmacytoid dendritic cell number ( J:152288 )

• in mice older than 9 months, the proportion and total number of plasmacytoid dendritic cells is increased 2-fold compared to in wild-type mice