Phenotypes associated with this allele

• Allele Symbol: Bicc1^tm1Bdc
• Allele Name: targeted mutation 1, Daniel B Constam
• Allele ID: MGI:4356450
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bicc1^tm1Bdc/Bicc1^tm1Bdc	involves: 129 * C57BL/6	MGI:4356462

Genotype
MGI:4356462

hm1

• Allelic Composition: Bicc1^tm1Bdc/Bicc1^tm1Bdc
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:152173 )

• all mice die 2 to 15 days after birth of renal failure

prenatal lethality, incomplete penetrance ( J:152173 )

• 50% of mice die in utero

embryo

abnormal embryonic cilium location or orientation ( J:152173 )

• 38% of cilia emanate from the posterior hemisphere of the ventral node compared to 82% in wild-type mice

• cilia exhibit perturbed rotational axes compared to in wild-type mice

abnormal motile primary cilium physiology ( J:152173 )

• flow generated by cilia is less directed or in rare cases diverted to the right unlike in wild-type mice

• cilia transport beads implanted into the node in all directions unlike in wild-type nodes in which 50% of the beads are moved to the left

growth/size/body

situs ambiguus ( J:152173 )

• 6% of newborn mice exhibit situs ambiguus

• at E13.5 to E15.5, 41% of mice exhibit situs ambiguus

situs inversus ( J:152173 )

• in 53% of newborn mice

renal/urinary system

kidney failure ( J:152173 )

• all mice die 2 to 15 days after birth of renal failure

cardiovascular system

ventricular septal defect ( J:152173 )

• at E13.5 to E15.5, 54% of mice exhibit ventricular septal heart defects

cellular

abnormal embryonic cilium location or orientation ( J:152173 )

• 38% of cilia emanate from the posterior hemisphere of the ventral node compared to 82% in wild-type mice

• cilia exhibit perturbed rotational axes compared to in wild-type mice

abnormal motile primary cilium physiology ( J:152173 )

• flow generated by cilia is less directed or in rare cases diverted to the right unlike in wild-type mice

• cilia transport beads implanted into the node in all directions unlike in wild-type nodes in which 50% of the beads are moved to the left