Phenotypes associated with this allele

• Allele Symbol: Tg(Cd4-Dtx1)1Mzl
• Allele Name: transgene insertion 1, Ming-Zong Lai
• Allele ID: MGI:4355027
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cd4-Dtx1)1Mzl/?	involves: C57BL/6	MGI:4355049

Genotype
MGI:4355049

tg1

• Allelic Composition: Tg(Cd4-Dtx1)1Mzl/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:151605 )

• T cells produce less IL-2 after activation compared to controls

decreased T cell proliferation ( J:151605 )

• acitvation induced T cell proliferation is decreased relative to controls

abnormal thymocyte activation ( J:151605 )

• thymocyte proliferation and IL-2 secretion after activation is reduced compared to controls

decreased interleukin-2 secretion ( J:151605 )

• thymocytes and T cells produce less IL-2 after activation relative to controls

hematopoietic system

abnormal T cell activation ( J:151605 )

• T cells produce less IL-2 after activation compared to controls

decreased T cell proliferation ( J:151605 )

• acitvation induced T cell proliferation is decreased relative to controls

abnormal thymocyte activation ( J:151605 )

• thymocyte proliferation and IL-2 secretion after activation is reduced compared to controls

endocrine/exocrine glands

abnormal thymocyte activation ( J:151605 )

• thymocyte proliferation and IL-2 secretion after activation is reduced compared to controls

cellular

decreased T cell proliferation ( J:151605 )

• acitvation induced T cell proliferation is decreased relative to controls