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Allele Symbol Allele Name Allele ID |
Dlg1tm1.1Agri targeted mutation 1.1, Anne Griep MGI:4354826 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P2, levels of apoptosis in the epithelium are increased compared to in wild-type mice
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• in the anterior, posterior, and center of the lens
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• lenses exhibit an abnormal shape with shortened anterior-posterior dimension
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• denucleation of the fiber cell compartment is delayed compared to in wild-type mice
• anterior and posterior suture formation is defective
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• at E13.5, lens epithelium is thickened and contains disorganized areas unlike in wild-type mice due to increased cell numbers
• at P2, the integrity of the lens epithelium is severely disrupted compared to in wild-type mice
• the central epithelium in lenses appears flattened and the uniform positioning of nuclei within cells is lost unlike in wild-type mice
• lens contain loosely packed cells, clusters of nuclei followed by gaps in the row of nuclei and vacuoles along with a few areas of multilayering in the peripheral epithelium unlike in wild-type mice
• however, at P2 the number of epithelial cells is normal
• at P24, a few areas of multilayering and irregular nuclei shapes are still observed in the peripheral epithelium and the central epithelium remained flattened unlike in wild-type mice
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• in some mice fiber cells fail to exhibit convex curvature and in other cases have an irregular curvature unlike in wild-type mice
• differentiation of fiber cells is disrupted
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• at P2
|
|
• at P2, levels of apoptosis in the epithelium are increased compared to in wild-type mice
|
|
• in the anterior, posterior, and center of the lens
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in the anterior, posterior, and center of the lens
|
|
• lenses exhibit an abnormal shape with shortened anterior-posterior dimension
|
|
• denucleation of the fiber cell compartment is delayed compared to in wild-type mice
• anterior and posterior suture formation is defective
• differentiation of fiber cells is disrupted
|
|
• in some mice fiber cells fail to exhibit convex curvature and in other cases have an irregular curvature unlike in wild-type mice
• differentiation of fiber cells is disrupted
|
|
• at P2
|
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• in the anterior, posterior, and center of the lens
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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