Phenotypes associated with this allele

• Allele Symbol: Cacna1g^tm1.3Ksak
• Allele Name: targeted mutation 1.3, Kenji Sakimura
• Allele ID: MGI:4354305
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1g^tm1.3Ksak/Cacna1g^tm1.3Ksak	involves: C57BL/6	MGI:4354647
hm2	Cacna1g^tm1.3Ksak/Cacna1g^tm1.3Ksak	involves: C57BL/6 * CBA	MGI:4354649

Genotype
MGI:4354647

hm1

• Allelic Composition: Cacna1g^tm1.3Ksak/Cacna1g^tm1.3Ksak
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal single cell response ( J:151465 )

• Purkinje cells lack T-type whole-cell calcium ion currents during depolarization unlike wild-type cells

Genotype
MGI:4354649

hm2

• Allelic Composition: Cacna1g^tm1.3Ksak/Cacna1g^tm1.3Ksak
• Genetic Background: involves: C57BL/6 * CBA

behavior/neurological

impaired behavioral response to xenobiotic ( J:151612 )

• time to loss of righting reflex following treatment with volatile isoflurane, halothane, or sevofluane is lengthened compared to in similarly treated wild-type mice

• however, mice exhibit normal time to loss of withdrawal reflex, duration of loss of righting reflex, and recovery time following anesthetic treatment

• time to loss of righting reflex following intraveanous treatment with pentobarbital is lengthened compared to in similarly treated wild-type mice

• however, response to intravenous ketamine treatment is normal