Phenotypes associated with this allele

• Allele Symbol: Tg(CTSG-RARA/PML)2544Ley
• Allele Name: transgene insertion 2544, Timothy Ley
• Allele ID: MGI:4353271
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CTSG-PML/RARA)135Ley/0 Tg(CTSG-RARA/PML)2544Ley/0	involves: C3H * C57BL/6	MGI:4353301
tg2	Tg(CTSG-RARA/PML)2544Ley/0	involves: C3H * C57BL/6	MGI:4353339

Genotype
MGI:4353301

cx1

• Allelic Composition: Tg(CTSG-PML/RARA)135Ley/0; Tg(CTSG-RARA/PML)2544Ley/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased acute promyelocytic leukemia incidence ( J:59080 )

• 7 of 36 (19.4%) and 16 of 28 (57%) doubly transgenic mice of independent cohorts developed acute premyelocytic leukemia (APML) b7 of 36 (19.4%) and 16 of 28 (57%) doubly transgenic mice of independent cohorts developed acute premyelocytic leukemia (APML) by 12 and 24 months of age, respectively

Genotype
MGI:4353339

tg2

• Allelic Composition: Tg(CTSG-RARA/PML)2544Ley/0
• Genetic Background: involves: C3H * C57BL/6

neoplasm

neoplasm ( J:59080 )

N • this transgene alone does not cause leukemia; more than 40 transgenic mice aged longer than 2 years failed to exhibit clinical or histologic evidence of the disease