Phenotypes associated with this allele

• Allele Symbol: Ppp2r5d^{Gt(RRT114)Byg}
• Allele Name: gene trap RRT114, BayGenomics
• Allele ID: MGI:4340650
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp2r5d^Gt(RRT114)Byg/Ppp2r5d^Gt(RRT114)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:8169075
cx2	Ppp2r5c^Gt(XP0444)Wtsi/Ppp2r5c^Gt(XP0444)Wtsi Ppp2r5d^Gt(RRT114)Byg/Ppp2r5d^Gt(RRT114)Byg	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:8169097

Genotype
MGI:8169075

hm1

• Allelic Composition: Ppp2r5d^{Gt(RRT114)Byg}/Ppp2r5d^{Gt(RRT114)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:348684 )

N • mice exhibit no obvious developmental defects

Genotype
MGI:8169097

cx2

• Allelic Composition: Ppp2r5c^{Gt(XP0444)Wtsi}/Ppp2r5c^{Gt(XP0444)Wtsi}; Ppp2r5d^{Gt(RRT114)Byg}/Ppp2r5d^{Gt(RRT114)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

mortality/aging

embryonic lethality, complete penetrance ( J:348684 )

• all double homozygotes are embryonic lethal; development is arrested around E12

embryo

embryonic growth arrest ( J:348684 )

• embryonic development is arrested around E12

growth/size/body

decreased fetal size ( J:348684 )

• at E14, fetal size is smaller than that in controls

• however, no size difference is noted at E12

cardiovascular system

persistent truncus arteriosus ( J:348684 )

• at E12, hearts exhibit a single outflow vessel rather than having both an aorta and a pulmonary artery

abnormal heart development ( J:348684 )

• heart development is arrested around E12, leading to death

• however, no major alterations are observed in myocardial, smooth muscle, or endothelial cell lineages

pericardial edema ( J:348684 )

• pericardial edema is noted at E12

increased fetal cardiomyocyte apoptosis ( J:348684 )

• at E12, hearts show a significantly higher number of caspase-3-positive cells than control hearts

limbs/digits/tail

abnormal limb development ( J:348684 )

• at E14, developing limbs appear underdeveloped

muscle

increased fetal cardiomyocyte apoptosis ( J:348684 )

• at E12, hearts show a significantly higher number of caspase-3-positive cells than control hearts

homeostasis/metabolism

pericardial edema ( J:348684 )

• pericardial edema is noted at E12

cellular

increased fetal cardiomyocyte apoptosis ( J:348684 )

• at E12, hearts show a significantly higher number of caspase-3-positive cells than control hearts

abnormal cell cycle ( J:348684 )

• a significantly greater percentage of mouse embryonic fibroblasts (MEFs) is found in the G2/M phase, suggesting a delay in progression through mitosis

decreased fibroblast proliferation ( J:348684 )

• in culture, mouse embryonic fibroblasts (MEFs) from E11 embryos fail to expand to the same extent as control MEFs; approximately 2- to 3-fold fewer MEFs are obtained by standard isolation procedures

nervous system

nervous system phenotype ( J:348684 )

N • no brain development defects are detected

behavior/neurological

behavior/neurological phenotype ( J:348684 )

N • no neurological development defects are detected