Phenotypes associated with this allele

• Allele Symbol: Mcph1^{Gt(RRO608)Byg}
• Allele Name: gene trap RRO608, BayGenomics
• Allele ID: MGI:4332146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcph1^Gt(RRO608)Byg/Mcph1^Gt(RRO608)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4438359

Genotype
MGI:4438359

hm1

• Allelic Composition: Mcph1^{Gt(RRO608)Byg}/Mcph1^{Gt(RRO608)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:157993 )

• difference in survival detectable after 65 weeks of age

premature death ( J:157993 )

• difference in survival detectable after 65 weeks of age

cellular

abnormal chromosome morphology ( J:157993 )

• primary fibroblasts show a dramatic increase of nuclei displaying condensed prophase-like chromatin

abnormal mitosis ( J:157993 )

• premature chromosome condensation and delayed decondensation in primary fibroblasts

reproductive system

reproductive system phenotype ( J:157993 )

N • in contrast to the defect in mitosis, no abnormalities in male meiosis are detected and both males and females are fertile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microcephaly		DOID:10907		J:157993