Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
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mortality/aging
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• no viable mice are present at birth
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Allelic
Composition |
Mcm3Gt(RRR002)Byg/Mcm3+
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Genetic
Background |
involves: 129P2/OlaHsd * C3HeB/FeJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
|
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cellular
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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hematopoietic system
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
|
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cellular
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
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cellular
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
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cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
Mcm7Gt(YTA285)Byg mutation
(0 available);
any
Mcm7 mutation
(45 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
Mcm7Gt(YTA285)Byg mutation
(0 available);
any
Mcm7 mutation
(45 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4chaos3 mutation
(1 available);
any
Mcm4 mutation
(42 available)
|
|
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mortality/aging
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• lifespan is expanded compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice but all mice die by 12 months of age
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• mortality observed in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice is largely rescued
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neoplasm
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• onset of tumorigenesis (lymphoma, thymoma, bone tumors, and liver tumors) is delayed or eliminated compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
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hematopoietic system
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N |
• the ratio of CD71+ reticulocytes to total red blood cells is completely corrected compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
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cellular
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• mouse embryonic fibroblast proliferation (MEFs) is partially rescued compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 MEFs
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
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embryo
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• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4chaos3/Mcm4chaos3 cells but improved 2.5- to 10-fold compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 cells
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growth/size/body
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N |
• body weight is rescued compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4chaos3 mutation
(1 available);
any
Mcm4 mutation
(42 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
|
|
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mortality/aging
|
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• mice die sooner than Mcm4chaos3 homozygotes
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• postnatal mortality observed in Mcm4chaos3/Mcm4Gt(RRE056)Byg mice is partially rescued
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neoplasm
endocrine/exocrine glands
integument
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4chaos3 mutation
(1 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
|
mortality/aging
|
|
• mortality observed in Mcm4chaos3/Mcm4chaos3 Mcm6Gt(YHD248)Byg/Mcm6+ mice is partially rescued
|
neoplasm
|
|
• tumor latency is shorted than in Mcm4chaos3 homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4chaos3 mutation
(1 available);
any
Mcm4 mutation
(42 available)
|
|
|
endocrine/exocrine glands
|
|
• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4chaos3 homozygotes
|
mortality/aging
|
N |
• lifespan is expanded compared to in Mcm4chaos3 homozygotes
|
neoplasm
|
N |
• mice do not develop lymphomas or thymomas unlike Mcm4chaos3 homozygotes
|
|
|
• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4chaos3 homozygotes
|
integument
|
|
• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4chaos3 homozygotes
|
embryo
|
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• mouse embryonic fibroblasts exhibit increased ability to form induced pluripotent stem cells compared with Mcm4chaos3/Mcm4chaos3 cells
|
Analysis Tools
