Phenotypes associated with this allele

• Allele Symbol: Arhgap21^{Gt(RRR629)Byg}
• Allele Name: gene trap RRR629, BayGenomics
• Allele ID: MGI:4330478
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgap21^Gt(RRR629)Byg/Arhgap21^Gt(RRR629)Byg	B6.129P2-Arhgap21^Gt(RRR629)Byg	MGI:6196211
ht2	Arhgap21^Gt(RRR629)Byg/Arhgap21^+	B6.129P2-Arhgap21^Gt(RRR629)Byg	MGI:6196212

Genotype
MGI:6196211

hm1

• Allelic Composition: Arhgap21^{Gt(RRR629)Byg}/Arhgap21^{Gt(RRR629)Byg}
• Genetic Background: B6.129P2-Arhgap21^{Gt(RRR629)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:262703 )

• mice die at E8

Genotype
MGI:6196212

ht2

• Allelic Composition: Arhgap21^{Gt(RRR629)Byg}/Arhgap21⁺
• Genetic Background: B6.129P2-Arhgap21^{Gt(RRR629)Byg}

hematopoietic system

increased megakaryocyte cell number ( J:262703 )

• 2-fold increase in frequency

decreased erythroid progenitor cell number ( J:262703 )

• 2-fold decrease in the bone marrow and spleen

• however, late subtypes of erythroid differentiation is normal

increased megakaryocyte progenitor cell number ( J:262703 )

decreased erythrocyte cell number ( J:262703 )

decreased hemoglobin content ( J:262703 )

thrombocytopenia ( J:262703 )

increased leukocyte cell number ( J:262703 )

• however, the percentage of B220+ B lymphocytes and T lymphocytes are normal

increased neutrophil cell number ( J:262703 )

decreased hematopoietic stem cell number ( J:262703 )

• in the bone marrow

abnormal hematopoietic stem cell physiology ( J:262703 )

• enhanced egress from the bone marrow with reduced fibronectin adhesion

homeostasis/metabolism

increased susceptibility to injury ( J:262703 )

• mice treated with 5-fluorouracil exhibit increased neutrophils likely due to increased hematopoietic stem cells but decreased colonies forming units (CFU-GEMM, combined number of CFU-GM, CFU-G and CFU-M, and BFU-E) in the bone marrow and hematocrit compared with wild-type mice

immune system

increased leukocyte cell number ( J:262703 )

• however, the percentage of B220+ B lymphocytes and T lymphocytes are normal

increased neutrophil cell number ( J:262703 )