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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		CttnGt(RRS284)Byg
gene trap RRS284, BayGenomics
MGI:4330257
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		CttnGt(RRS284)Byg/CttnGt(RRS284)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:4437715
ht2
 		CttnGt(RRS284)Byg/Cttn+ involves: 129P2/OlaHsd * C57BL/6 MGI:4437714


Genotype
MGI:4437715
hm1
Allelic
Composition		 CttnGt(RRS284)Byg/CttnGt(RRS284)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CttnGt(RRS284)Byg mutation (1 available); any Cttn mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:158029 )
• zygotes die prior to the 2-cell stage

embryo
abnormal preimplantation embryo development ( J:158029 )
• 75% of zygotes exhibit either no second polar body or abnormal morphology such as significant cellular fragmentation compared with wild-type zygotes
failure of zygotic cell division ( J:158029 )
• zygotes die prior to the 2-cell stage

reproductive system
abnormal secondary polar body morphology ( J:158029 )
• 75% of zygotes exhibit either no second polar body or abnormal morphology

cellular
abnormal secondary polar body morphology ( J:158029 )
• 75% of zygotes exhibit either no second polar body or abnormal morphology




Genotype
MGI:4437714
ht2
Allelic
Composition		 CttnGt(RRS284)Byg/Cttn+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CttnGt(RRS284)Byg mutation (1 available); any Cttn mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:158029 )
• an increased proportion of embryos that expected is observed

cellular
abnormal cell morphology ( J:158029 )
• mouse embryonic fibroblasts exhibit impaired actin dynamics compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory