All Phenotypes Nckap1<Gt(RRQ139)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nckap1^{Gt(RRQ139)Byg}
gene trap RRQ139, BayGenomics
MGI:4330168

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nckap1^{Gt(RRQ139)Byg}/Nckap1^{Gt(RRQ139)Byg}	involves: 129P2/OlaHsd * C3H	MGI:5050116

Allelic Composition	Nckap1^{Gt(RRQ139)Byg}/Nckap1^{Gt(RRQ139)Byg}
Genetic Background	involves: 129P2/OlaHsd * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nckap1^{Gt(RRQ139)Byg} mutation (0 available); any Nckap1 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:166095 )

• expression analysis indicates anterior visceral endoderm cells fail to migrate from the distal tip to the embryonic-extraembryonic boundary by E6.5

cellular

increased apoptosis ( J:173526 )

• slightly increased at E7.5 with apoptotic cells scattered in a 3 germ layers

abnormal cell migration ( J:173526 )

• defect in formation of lamellipodia in cultured cells

abnormal anterior visceral endoderm cell migration ( J:166095 )

• expression analysis indicates anterior visceral endoderm cells fail to migrate from the distal tip to the embryonic-extraembryonic boundary by E6.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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