Phenotypes associated with this allele

• Allele Symbol: Hic2^{Gt(RRN127)Byg}
• Allele Name: gene trap RRN127, BayGenomics
• Allele ID: MGI:4329590
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hic2^Gt(RRN127)Byg/Hic2^Gt(RRN127)Byg	involves: 129P2/OlaHsd * C57BL/6J * CD-1	MGI:5707461
ht2	Hic2^Gt(RRN127)Byg/Hic2^+	B6.129P2-Hic2^Gt(RRN127)Byg	MGI:5707463

Genotype
MGI:5707461

hm1

• Allelic Composition: Hic2^{Gt(RRN127)Byg}/Hic2^{Gt(RRN127)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:225226 )

• Background Sensitivity: homozygotes all die before E10.5 but only survive to E9.5 on a C57BL/6 background

embryo

embryonic growth retardation ( J:225226 )

• mice are developmentally delayed 1 day (at E10.5)

cardiovascular system

cardiovascular system phenotype ( J:225226 )

N • mice have a morphologically normal heart at E10.5

growth/size/body

embryonic growth retardation ( J:225226 )

• mice are developmentally delayed 1 day (at E10.5)

Genotype
MGI:5707463

ht2

• Allelic Composition: Hic2^{Gt(RRN127)Byg}/Hic2⁺
• Genetic Background: B6.129P2-Hic2^{Gt(RRN127)Byg}

mortality/aging

preweaning lethality ( J:225226 )

• 31% lethality by 21 days of age

prenatal lethality, incomplete penetrance ( J:225226 )

• mice start to display lethality around E15.5

cardiovascular system

abnormal myocardium layer morphology ( J:225226 )

abnormal myocardial trabeculae morphology ( J:225226 )

• thin trabecular layer sometimes

thin myocardium ( J:225226 )

• sometimes

overriding aortic valve ( J:225226 )

• in 25% of E15.5 embryos

ventricular septal defect ( J:225226 )

• 36.5% of E15.5 embryos with ventricular septal defects

muscular ventricular septal defect ( J:225226 )

• sometimes a second muscular defect as well

muscle

abnormal myocardium layer morphology ( J:225226 )

abnormal myocardial trabeculae morphology ( J:225226 )

• thin trabecular layer sometimes

thin myocardium ( J:225226 )

• sometimes