All Phenotypes Kdm5b<Gt(RRO123)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm5b^{Gt(RRO123)Byg}/Kdm5b^{Gt(RRO123)Byg}	B6.129P2-Kdm5b^{Gt(RRO123)Byg}	MGI:5619599
hm2	Kdm5b^{Gt(RRO123)Byg}/Kdm5b^{Gt(RRO123)Byg}	FVB.129P2-Kdm5b^{Gt(RRO123)Byg}	MGI:5619600
hm3	Kdm5b^{Gt(RRO123)Byg}/Kdm5b^{Gt(RRO123)Byg}	involves: 129P2/OlaHsd * C57BL/6	MGI:5619601

Allelic Composition	Kdm5b^{Gt(RRO123)Byg}/Kdm5b^{Gt(RRO123)Byg}
Genetic Background	B6.129P2-Kdm5b^{Gt(RRO123)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5b^{Gt(RRO123)Byg} mutation (2 available); any Kdm5b mutation (198 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:218960 )

• Background Sensitivity: normal numbers of homozygotes are produced in heterozygous x heterozygous matings; however, numbers are reduced on the FVB/N background

• Background Sensitivity: the adult mortality rate is similar to control, however, the rate is higher in the mixed C57BL/6;129P2 and FVB/N backgrounds

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:218960 )

• Background Sensitivity: the adult mortality rate is higher in mice on the mixed and FVB/N backgrounds, but not on the C57BL/6 background

neonatal lethality, incomplete penetrance ( J:218960 )

• Background Sensitivity: fewer homozygotes are produced in heterozygous x heterozygous matings

homeostasis/metabolism

decreased circulating estradiol level ( J:218960 )

• serum 17beta-estradiol levels are reduced prior to 6 weeks of age

integument

abnormal mammary gland development ( J:218960 )

• delayed mammary gland development is observed in 5-6 week old females

• numbers of proliferating epithelial cells are reduced in the mammary glands from 5 week old females as compared to controls

abnormal branching of the mammary ductal tree ( J:218960 )

• mammary glands exhibit reduced numbers of terminal end buds, secondary branching and outgrowth length, however, differences disappear by 3 months of age

endocrine/exocrine glands

abnormal mammary gland development ( J:218960 )

• delayed mammary gland development is observed in 5-6 week old females

• numbers of proliferating epithelial cells are reduced in the mammary glands from 5 week old females as compared to controls

abnormal branching of the mammary ductal tree ( J:218960 )

• mammary glands exhibit reduced numbers of terminal end buds, secondary branching and outgrowth length, however, differences disappear by 3 months of age

reproductive system

decreased uterus weight ( J:218960 )

• uterine weight is decreased at 5-6 weeks, but is similar to controls by 7 weeks

female infertility ( J:218960 )

• females older than 3 months are infertile

reduced female fertility ( J:218960 )

• pregnancy rate is lower in 6-12 week old females

Allelic Composition	Kdm5b^{Gt(RRO123)Byg}/Kdm5b^{Gt(RRO123)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5b^{Gt(RRO123)Byg} mutation (2 available); any Kdm5b mutation (198 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:218960 )

• mice weigh less than wild-type from pre weaning age to early adulthood

mortality/aging

premature death ( J:218960 )

• Background Sensitivity: the adult mortality rate is higher in mice on the mixed and FVB/N backgrounds, but not on the C57BL/6 background

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