Analysis Tools
mortality/aging
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• mice are born alive but some die within 48 hours of birth
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• mice are born alive but some die within 48 hours of birth with fewer than expected mice present at weaning
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cardiovascular system
| N |
• mice exhibit normal cardiac development
• adult mice exhibit normal left ventricular wall thickness and inner chamber dimensions during the cardiac cycle
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• associated with vascular thrombi
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• vascular thrombi is associated with dilatation of atria and coronary vasculature and lung congestion
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• elongated leaflets with increased surface area to volume ratios in the mitral and tricuspid valves
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• long and thin valves with increased leaflet surface area to volume ratios
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• increased diameter
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• long and thin valves with increased leaflet surface area to volume ratios
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• increased diameter
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• adult mice exhibit elevated myocardial performance index (Tei index) compared with wild-type mice
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homeostasis/metabolism
| N |
• mice exhibit normal coagulation factor function as accessed by prothrombin time and partial thromboplastin time test
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• vascular thrombi are associated with dilatation of atria and coronary vasculature and lung congestion
• mural thrombus in the right ventricle and organized thrombus in umbilical vessel with evidence of recanalization
• early organizing thrombi in the arterioles of lungs in almost all non-surviving mice with clots in the hepatic vein (in 5 of 6 mice) and coronary vessel (in 4 of 6 mice)
• however, no organized thrombi are observed prior to birth
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• blood clots attached to atrioventricular valves in non-surviving mice
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• even in mice that escape premature death
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immune system
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• slight
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• slight
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growth/size/body
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• at 3 months
• however, birth weight is normal
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respiratory system
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• associated with vascular thrombi
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liver/biliary system
| N |
• mice exhibit normal liver chemistry
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hematopoietic system
| N |
• mice exhibit normal red blood cells, hemoglobin and platelets
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• slight
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• slight
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