Phenotypes associated with this allele

• Allele Symbol: Agpat2^{Gt(OST438470)Lex}
• Allele Name: gene trap OST438470, Lexicon Genetics
• Allele ID: MGI:4317356
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agpat2^Gt(OST438470)Lex/Agpat2^Gt(OST438470)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5431431

Genotype
MGI:5431431

hm1

• Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186035 )

• relatively few mice survive beyond 3 months

postnatal lethality, incomplete penetrance ( J:186035 )

• most mice die during the first 2 weeks after birth

cellular

adipose tissue necrosis ( J:186035 )

• type 1 brown adipose tissue exhibits massive necrosis

adipose tissue

decreased white adipose tissue amount ( J:186035 )

• absent in aged mice

abnormal brown adipose tissue morphology ( J:186035 )

• type 1 brown adipose tissue exhibits massive necrosis and granulomatous inflammation

• type 2 brown adipose tissue exhibits enlarged vesicles in many cells without necrosis or inflammation

decreased brown adipose tissue amount ( J:186035 )

• absent in aged mice

abnormal white fat cell morphology ( J:186035 )

• the few adipocytes present in the dermis are widely scattered between hair follicles

• adipocytes lack the large unilocular fat droplet and flattened peripherally displaced nucleus as in wild-type cells

decreased white fat cell number ( J:186035 )

• at 1 week, mice essentially lack dermal and hypodermal white adipose tissue adipocytes

decreased white fat cell size ( J:186035 )

• at 1 week

adipose tissue necrosis ( J:186035 )

• type 1 brown adipose tissue exhibits massive necrosis

lipodystrophy ( J:186035 )

brown adipose tissue inflammation ( J:186035 )

• type 1 brown adipose tissue exhibits granulomatous inflammation

craniofacial

abnormal incisor morphology ( J:186035 )

• severe bilateral dental dysplasia involving the incisor teeth with loss of ameloblasts resulting in enamel hypoplasia and disordered growth and orientation of dentin

abnormal dentin development ( J:186035 )

• disordered growth and orientation of dentin

ameloblast degeneration ( J:186035 )

reduced enamel thickness ( J:186035 )

• enamel hypoplasia

liver/biliary system

liver inflammation ( J:186035 )

• scattered foci of mild inflammation

abnormal liver morphology ( J:186035 )

• liver floats in fixative

enlarged liver ( J:186035 )

• severe

microvesicular hepatic steatosis ( J:186035 )

• severe microvesicular hepatocellular steatosis in aged mice

pale liver ( J:186035 )

homeostasis/metabolism

increased circulating glucose level ( J:186035 )

• 3-fold in the fed state greater between 5 and 11 weeks

hyperglycemia ( J:186035 )

• in the fed state by 1 week of age

• chronic in young and old mice

increased circulating insulin level ( J:186035 )

• in the fed state beginning at birth

• in the fasted state

• in fasted and refed mice

growth/size/body

abnormal incisor morphology ( J:186035 )

• severe bilateral dental dysplasia involving the incisor teeth with loss of ameloblasts resulting in enamel hypoplasia and disordered growth and orientation of dentin

abnormal dentin development ( J:186035 )

• disordered growth and orientation of dentin

ameloblast degeneration ( J:186035 )

reduced enamel thickness ( J:186035 )

• enamel hypoplasia

decreased body size ( J:186035 )

• in mice that survive beyond weaning

distended abdomen ( J:186035 )

enlarged liver ( J:186035 )

• severe

integument

rough coat ( J:186035 )

limbs/digits/tail

femur fracture ( J:186035 )

• proximal femoral fractures in 2 of the 4 mice

skeleton

abnormal incisor morphology ( J:186035 )

• severe bilateral dental dysplasia involving the incisor teeth with loss of ameloblasts resulting in enamel hypoplasia and disordered growth and orientation of dentin

abnormal dentin development ( J:186035 )

• disordered growth and orientation of dentin

ameloblast degeneration ( J:186035 )

reduced enamel thickness ( J:186035 )

• enamel hypoplasia

femur fracture ( J:186035 )

• proximal femoral fractures in 2 of the 4 mice

endocrine/exocrine glands

increased pancreatic beta cell number ( J:186035 )

enlarged pancreatic islets ( J:186035 )

immune system

brown adipose tissue inflammation ( J:186035 )

• type 1 brown adipose tissue exhibits granulomatous inflammation

granulomatous inflammation ( J:186035 )

• in type 1 brown adipose tissue

liver inflammation ( J:186035 )

• scattered foci of mild inflammation