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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pacs2Gt(OST426086)Lex
gene trap OST426086, Lexicon Genetics
MGI:4313108
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pacs2Gt(OST426086)Lex/Pacs2Gt(OST426086)Lex involves: 129S5/SvEvBrd * NIH Black Swiss MGI:4410463


Genotype
MGI:4410463
hm1
Allelic
Composition
Pacs2Gt(OST426086)Lex/Pacs2Gt(OST426086)Lex
Genetic
Background
involves: 129S5/SvEvBrd * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pacs2Gt(OST426086)Lex mutation (0 available); any Pacs2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type micemice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type mice
• however, anti-Fas antibody Jo2- or LPS/galactosamine-induced hepatic apoptosis is normal

homeostasis/metabolism
• mice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type micemice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type mice
• however, TRAIl-induced liver steatosis is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory