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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Parp14Gt(OST415485)Lex
gene trap OST415485, Lexicon Genetics
MGI:4310014
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Parp14Gt(OST415485)Lex/Parp14Gt(OST415485)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5555959


Genotype
MGI:5555959
hm1
Allelic
Composition		 Parp14Gt(OST415485)Lex/Parp14Gt(OST415485)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parp14Gt(OST415485)Lex mutation (0 available); any Parp14 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:146533 )
• in response to irradiation despite IL4 treatment
decreased B cell proliferation ( J:146533 )
• in response to anti-IgM with IL4 treatment
increased B cell proliferation ( J:146533 )
• 1.4-fold in response to anti-IgM treatment
• however, addition of IL4 fails to further increase proliferation
decreased IgA level ( J:146533 )
• in response to KLH

cellular
increased cellular sensitivity to gamma-irradiation ( J:146533 )
• decreased B cell apoptosis despite IL4 treatment
increased B cell apoptosis ( J:146533 )
• in response to irradiation despite IL4 treatment
decreased B cell proliferation ( J:146533 )
• in response to anti-IgM with IL4 treatment
increased B cell proliferation ( J:146533 )
• 1.4-fold in response to anti-IgM treatment
• however, addition of IL4 fails to further increase proliferation

hematopoietic system
increased B cell apoptosis ( J:146533 )
• in response to irradiation despite IL4 treatment
decreased B cell proliferation ( J:146533 )
• in response to anti-IgM with IL4 treatment
increased B cell proliferation ( J:146533 )
• 1.4-fold in response to anti-IgM treatment
• however, addition of IL4 fails to further increase proliferation
decreased IgA level ( J:146533 )
• in response to KLH




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory