All Phenotypes Fbxl5<Gt(OST386421)Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fbxl5^{Gt(OST386421)Lex}
gene trap OST386421, Lexicon Genetics
MGI:4302129

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex}	involves: 129S5/SvEvBrd * C57BL/6	MGI:5470104
ht2	Fbxl5^{Gt(OST386421)Lex}/Fbxl5⁺	129S(B6)-Fbxl5^{Gt(OST386421)Lex}	MGI:5470105
ht3	Fbxl5^{Gt(OST386421)Lex}/Fbxl5⁺	involves: 129S5/SvEvBrd * C57BL/6	MGI:5470106
cx4	Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex} Ireb2^tm1.2Mwh/Ireb2^tm1.2Mwh	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:5470107
cx5	Aco1^tm1.2Mwh/Aco1^tm1.2Mwh Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex}	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:5470108

Allelic Composition	Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex}
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5^{Gt(OST386421)Lex} mutation (0 available); any Fbxl5 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation of Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex} embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:193752 )

• mice die between E11.5 and E12.5

embryo

embryonic growth retardation ( J:193752 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:193752 )

• at E9.5

Allelic Composition	Fbxl5^{Gt(OST386421)Lex}/Fbxl5⁺
Genetic Background	129S(B6)-Fbxl5^{Gt(OST386421)Lex}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5^{Gt(OST386421)Lex} mutation (0 available); any Fbxl5 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythrocyte morphology ( J:193752 )

• despite low serum iron levels, mice fed a low iron diet do not exhibit a reduction in hematocrit, hemoglobin or erythrocyte levels unlike wild-type mice

Allelic Composition	Fbxl5^{Gt(OST386421)Lex}/Fbxl5⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5^{Gt(OST386421)Lex} mutation (0 available); any Fbxl5 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron homeostasis ( J:193752 )

• mice fed a low iron diet exhibit enhanced duodenum uptake and preferential iron storage in the spleen and bone marrow for rapid incorporation into red blood cells unlike wild-type mice

increased intestine iron level ( J:193752 )

• enhanced duodenum uptake in mice fed a low iron diet

increased spleen iron level ( J:193752 )

• in mice fed a low iron diet

decreased liver iron level ( J:193752 )

• in mice fed a low iron diet

hematopoietic system

abnormal erythrocyte morphology ( J:193752 )

• despite low serum iron levels, mice fed a low iron diet do not exhibit a reduction in hematocrit, hemoglobin or erythrocyte levels unlike wild-type mice

increased spleen iron level ( J:193752 )

• in mice fed a low iron diet

digestive/alimentary system

increased intestine iron level ( J:193752 )

• enhanced duodenum uptake in mice fed a low iron diet

immune system

increased spleen iron level ( J:193752 )

• in mice fed a low iron diet

liver/biliary system

decreased liver iron level ( J:193752 )

• in mice fed a low iron diet

Allelic Composition	Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex} Ireb2^tm1.2Mwh/Ireb2^tm1.2Mwh
Genetic Background	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5^{Gt(OST386421)Lex} mutation (0 available); any Fbxl5 mutation (43 available)
Ireb2^tm1.2Mwh mutation (0 available); any Ireb2 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:193752 )

N	• mice are viable

hematopoietic system

anemia ( J:193752 )

Allelic Composition	Aco1^tm1.2Mwh/Aco1^tm1.2Mwh Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex}
Genetic Background	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aco1^tm1.2Mwh mutation (0 available); any Aco1 mutation (50 available)
Fbxl5^{Gt(OST386421)Lex} mutation (0 available); any Fbxl5 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:193752 )

• no mice are observed at birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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