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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxl5Gt(OST386421)Lex
gene trap OST386421, Lexicon Genetics
MGI:4302129
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5470104
ht2
 		Fbxl5Gt(OST386421)Lex/Fbxl5+ 129S(B6)-Fbxl5Gt(OST386421)Lex MGI:5470105
ht3
 		Fbxl5Gt(OST386421)Lex/Fbxl5+ involves: 129S5/SvEvBrd * C57BL/6 MGI:5470106
cx4
 		Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Ireb2tm1.2Mwh/Ireb2tm1.2Mwh 		involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6 MGI:5470107
cx5
 		Aco1tm1.2Mwh/Aco1tm1.2Mwh
Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex 		involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6 MGI:5470108


Genotype
MGI:5470104
hm1
Allelic
Composition		 Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5Gt(OST386421)Lex mutation (0 available); any Fbxl5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Growth retardation of Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex embryos

mortality/aging

embryo

growth/size/body
embryonic growth retardation ( J:193752 )
• at E9.5




Genotype
MGI:5470105
ht2
Allelic
Composition		 Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic
Background		 129S(B6)-Fbxl5Gt(OST386421)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5Gt(OST386421)Lex mutation (0 available); any Fbxl5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythrocyte morphology ( J:193752 )
• despite low serum iron levels, mice fed a low iron diet do not exhibit a reduction in hematocrit, hemoglobin or erythrocyte levels unlike wild-type mice




Genotype
MGI:5470106
ht3
Allelic
Composition		 Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5Gt(OST386421)Lex mutation (0 available); any Fbxl5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron homeostasis ( J:193752 )
• mice fed a low iron diet exhibit enhanced duodenum uptake and preferential iron storage in the spleen and bone marrow for rapid incorporation into red blood cells unlike wild-type mice
increased intestinal iron level ( J:193752 )
• enhanced duodenum uptake in mice fed a low iron diet
increased spleen iron level ( J:193752 )
• in mice fed a low iron diet
decreased liver iron level ( J:193752 )
• in mice fed a low iron diet

hematopoietic system
abnormal erythrocyte morphology ( J:193752 )
• despite low serum iron levels, mice fed a low iron diet do not exhibit a reduction in hematocrit, hemoglobin or erythrocyte levels unlike wild-type mice
increased spleen iron level ( J:193752 )
• in mice fed a low iron diet

digestive/alimentary system
increased intestinal iron level ( J:193752 )
• enhanced duodenum uptake in mice fed a low iron diet

immune system
increased spleen iron level ( J:193752 )
• in mice fed a low iron diet

liver/biliary system
decreased liver iron level ( J:193752 )
• in mice fed a low iron diet




Genotype
MGI:5470107
cx4
Allelic
Composition		 Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5Gt(OST386421)Lex mutation (0 available); any Fbxl5 mutation (45 available)
Ireb2tm1.2Mwh mutation (0 available); any Ireb2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:193752 )
N
• mice are viable

hematopoietic system




Genotype
MGI:5470108
cx5
Allelic
Composition		 Aco1tm1.2Mwh/Aco1tm1.2Mwh
Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aco1tm1.2Mwh mutation (0 available); any Aco1 mutation (51 available)
Fbxl5Gt(OST386421)Lex mutation (0 available); any Fbxl5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:193752 )
• no mice are observed at birth




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory