All Phenotypes Hdac4<Gt(OST361114)Lex> MGI Mouse

abnormal involuntary movement ( J:152466 )

• mice exhibit unilateral eye blinks and ear twitches in the absence of overt seizures unlike wild-type mice

• seizures are preceded by eye blinking, and after seizures mice exhibit residual ear and eye twitches

increased blinking frequency ( J:152466 )

• following seizures, mice exhibit residual ear and eye twitches

• mice exhibit unilateral eye blinks and ear twitches in the absence of overt seizures unlike wild-type mice

increased locomotor activity ( J:152466 )

• female, but not male, mice exhibit increased distance travel in an open field test compared with wild-type mice

increased thermal nociceptive threshold ( J:152466 )

• male and female mice exhibit increased latency to respond in a hot plate assay compared with wild-type mice

• however, nociception in a formalin test is normal

environmentally induced seizures ( J:152466 )

• after 5 months, some mice exhibit seizures after handling

convulsive seizures ( J:152466 )

• after 5 months, 10 of 26 mice exhibit spontaneous convulsive seizures compared with 2 to 11 wild-type mice

• seizures occur when cage is opened or after mice handling, are preceded by eye blinking, and consist of head tilt, eye closure, and full body muscle spasm, followed by falling onto the side and continuing to spasm for 1 to 10 seconds

tonic seizures ( J:152466 )

abnormal spike wave discharge ( J:152466 )

• seizure activity characterized by fast spiking concurrence with muscle potential during the tonic phase

• termination of convulsion is characterized by electroencephalographic voltage depression after a slow spike transition

nervous system phenotype ( J:152466 )

N	• unlike in Hdac4^tm1Eno homozygotes, the brain and spinal cord are normal