Phenotypes associated with this allele

• Allele Symbol: Rras2^{Gt(OST361011)Lex}
• Allele Name: gene trap OST361011, Lexicon Genetics
• Allele ID: MGI:4294133
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rras2^Gt(OST361011)Lex/Rras2^Gt(OST361011)Lex	B6.129S5-Rras2^Gt(OST361011)Lex	MGI:4355172
hm2	Rras2^Gt(OST361011)Lex/Rras2^Gt(OST361011)Lex	involves: 129S5/SvEvBrd	MGI:4355164
ht3	Rras2^Gt(OST361011)Lex/Rras2^+	involves: 129S5/SvEvBrd	MGI:4355171

Genotype
MGI:4355172

hm1

• Allelic Composition: Rras2^{Gt(OST361011)Lex}/Rras2^{Gt(OST361011)Lex}
• Genetic Background: B6.129S5-Rras2^{Gt(OST361011)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:151653 )

• B cell numbers in the spleen are reduced

decreased T cell number ( J:151653 )

• T cell numbers in the spleen are decreased

decreased memory T cell number ( J:151653 )

• decrease in numbers is more evident in the memory T cell population than in controls

hematopoietic system

decreased B cell number ( J:151653 )

• B cell numbers in the spleen are reduced

decreased T cell number ( J:151653 )

• T cell numbers in the spleen are decreased

decreased memory T cell number ( J:151653 )

• decrease in numbers is more evident in the memory T cell population than in controls

Genotype
MGI:4355164

hm2

• Allelic Composition: Rras2^{Gt(OST361011)Lex}/Rras2^{Gt(OST361011)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

immune system

decreased B cell number ( J:151653 )

• B cell numbers in the spleen are reduced by about 50%

decreased follicular B cell number ( J:151653 )

• follicular B cell numbers are reduced by about 30%

decreased marginal zone B cell number ( J:151653 )

• marginal zone B cells are decreased by more than 75%

decreased T cell number ( J:151653 )

• T cell numbers in the spleen are decreased about 30%

decreased memory T cell number ( J:151653 )

• decrease in numbers is more evident in the memory T cell population than in controls

decreased spleen weight ( J:151653 )

• spleen weight is reduced by about 20-30%

spleen hypoplasia ( J:151653 )

• spleen cellularity is reduced by about a third

decreased spleen B cell follicle size ( J:151653 )

• spleen B cell follicles are smaller with fewer cells

abnormal B cell physiology ( J:151653 )

• homeostatic proliferation of mutant B cells transferred into a lymphopenic host is less than controls

• one-tenth the number of mutant B cells survive as controls 21 days after being transferred into a lymphopenic hosts

abnormal B cell activation ( J:151653 )

• secondary responses to a T cell-dependent antigen are lower as measured by immunoglobulin secretion

decreased B cell proliferation ( J:151653 )

• in vitro B cell proliferation in response to a recall antigen is impaired

abnormal CD4-positive, alpha-beta T cell physiology ( J:151653 )

• one-quarter the number of mutant CD4 T cells survive as controls 21 days after being transferred into a lymphopenic hosts

abnormal CD8-positive, alpha-beta T cell physiology ( J:151653 )

• homeostatic proliferation of mutant CD8 T cells transferred into a lymphopenic host is less than controls

• one-fifth the number of mutant CD8 T cells survive as controls 21 days after being transferred into a lymphopenic hosts

abnormal lymph node germinal center morphology ( J:151653 )

• germinal centers are smaller and less numerous

hematopoietic system

decreased B cell number ( J:151653 )

• B cell numbers in the spleen are reduced by about 50%

decreased follicular B cell number ( J:151653 )

• follicular B cell numbers are reduced by about 30%

decreased marginal zone B cell number ( J:151653 )

• marginal zone B cells are decreased by more than 75%

decreased T cell number ( J:151653 )

• T cell numbers in the spleen are decreased about 30%

decreased memory T cell number ( J:151653 )

• decrease in numbers is more evident in the memory T cell population than in controls

decreased spleen weight ( J:151653 )

• spleen weight is reduced by about 20-30%

spleen hypoplasia ( J:151653 )

• spleen cellularity is reduced by about a third

decreased spleen B cell follicle size ( J:151653 )

• spleen B cell follicles are smaller with fewer cells

abnormal B cell physiology ( J:151653 )

• homeostatic proliferation of mutant B cells transferred into a lymphopenic host is less than controls

• one-tenth the number of mutant B cells survive as controls 21 days after being transferred into a lymphopenic hosts

abnormal B cell activation ( J:151653 )

• secondary responses to a T cell-dependent antigen are lower as measured by immunoglobulin secretion

decreased B cell proliferation ( J:151653 )

• in vitro B cell proliferation in response to a recall antigen is impaired

abnormal CD4-positive, alpha-beta T cell physiology ( J:151653 )

• one-quarter the number of mutant CD4 T cells survive as controls 21 days after being transferred into a lymphopenic hosts

abnormal CD8-positive, alpha-beta T cell physiology ( J:151653 )

• homeostatic proliferation of mutant CD8 T cells transferred into a lymphopenic host is less than controls

• one-fifth the number of mutant CD8 T cells survive as controls 21 days after being transferred into a lymphopenic hosts

cellular

decreased B cell proliferation ( J:151653 )

• in vitro B cell proliferation in response to a recall antigen is impaired

maternal effect ( J:151653 )

• fewer homozygous and heterozygous mice are born to heterozygous parent than expected (21% of the offspring are Rras2-/- and 49% of the offspring were Rras2+/-; n=378)

Genotype
MGI:4355171

ht3

• Allelic Composition: Rras2^{Gt(OST361011)Lex}/Rras2⁺
• Genetic Background: involves: 129S5/SvEvBrd

immune system

decreased B cell number ( J:151653 )

• B cell numbers in the spleen are reduced by about 50%

decreased follicular B cell number ( J:151653 )

• follicular B cell numbers are reduced by about 20%

decreased marginal zone B cell number ( J:151653 )

• marginal zone B cells are decreased by more than 50%

decreased T cell number ( J:151653 )

• T cell numbers in the spleen are decreased about 30%

decreased memory T cell number ( J:151653 )

• decrease in numbers is more evident in the memory T cell population than in controls

• decrease in memory T cells worsens with age of the mice

decreased spleen weight ( J:151653 )

• spleen weight is reduced by about 20-30%

spleen hypoplasia ( J:151653 )

• spleen cellularity is reduced by about a third

decreased spleen B cell follicle size ( J:151653 )

• spleen B cell follicles are smaller with fewer cells

hematopoietic system

decreased B cell number ( J:151653 )

• B cell numbers in the spleen are reduced by about 50%

decreased follicular B cell number ( J:151653 )

• follicular B cell numbers are reduced by about 20%

decreased marginal zone B cell number ( J:151653 )

• marginal zone B cells are decreased by more than 50%

decreased T cell number ( J:151653 )

• T cell numbers in the spleen are decreased about 30%

decreased memory T cell number ( J:151653 )

• decrease in numbers is more evident in the memory T cell population than in controls

• decrease in memory T cells worsens with age of the mice

decreased spleen weight ( J:151653 )

• spleen weight is reduced by about 20-30%

spleen hypoplasia ( J:151653 )

• spleen cellularity is reduced by about a third

decreased spleen B cell follicle size ( J:151653 )

• spleen B cell follicles are smaller with fewer cells

cellular

maternal effect ( J:151653 )

• fewer homozygous and heterozygous mice are born to heterozygous parent than expected (21% of the offspring are Rras2 -/- and 49% of the offspring were Rras2 +/-; n=378)