Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rras2Gt(OST361011)Lex mutation
(0 available);
any
Rras2 mutation
(31 available)
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immune system
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• B cell numbers in the spleen are reduced
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• T cell numbers in the spleen are decreased
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• decrease in numbers is more evident in the memory T cell population than in controls
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hematopoietic system
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• B cell numbers in the spleen are reduced
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• T cell numbers in the spleen are decreased
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• decrease in numbers is more evident in the memory T cell population than in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rras2Gt(OST361011)Lex mutation
(0 available);
any
Rras2 mutation
(31 available)
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immune system
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• B cell numbers in the spleen are reduced by about 50%
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• follicular B cell numbers are reduced by about 30%
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• marginal zone B cells are decreased by more than 75%
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• T cell numbers in the spleen are decreased about 30%
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• decrease in numbers is more evident in the memory T cell population than in controls
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• spleen weight is reduced by about 20-30%
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• spleen cellularity is reduced by about a third
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• spleen B cell follicles are smaller with fewer cells
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• homeostatic proliferation of mutant B cells transferred into a lymphopenic host is less than controls
• one-tenth the number of mutant B cells survive as controls 21 days after being transferred into a lymphopenic hosts
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• secondary responses to a T cell-dependent antigen are lower as measured by immunoglobulin secretion
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• in vitro B cell proliferation in response to a recall antigen is impaired
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• one-quarter the number of mutant CD4 T cells survive as controls 21 days after being transferred into a lymphopenic hosts
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• homeostatic proliferation of mutant CD8 T cells transferred into a lymphopenic host is less than controls
• one-fifth the number of mutant CD8 T cells survive as controls 21 days after being transferred into a lymphopenic hosts
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• germinal centers are smaller and less numerous
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hematopoietic system
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• B cell numbers in the spleen are reduced by about 50%
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• follicular B cell numbers are reduced by about 30%
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• marginal zone B cells are decreased by more than 75%
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• T cell numbers in the spleen are decreased about 30%
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• decrease in numbers is more evident in the memory T cell population than in controls
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• spleen weight is reduced by about 20-30%
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• spleen cellularity is reduced by about a third
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• spleen B cell follicles are smaller with fewer cells
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• homeostatic proliferation of mutant B cells transferred into a lymphopenic host is less than controls
• one-tenth the number of mutant B cells survive as controls 21 days after being transferred into a lymphopenic hosts
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• secondary responses to a T cell-dependent antigen are lower as measured by immunoglobulin secretion
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• in vitro B cell proliferation in response to a recall antigen is impaired
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• one-quarter the number of mutant CD4 T cells survive as controls 21 days after being transferred into a lymphopenic hosts
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• homeostatic proliferation of mutant CD8 T cells transferred into a lymphopenic host is less than controls
• one-fifth the number of mutant CD8 T cells survive as controls 21 days after being transferred into a lymphopenic hosts
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cellular
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• in vitro B cell proliferation in response to a recall antigen is impaired
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• fewer homozygous and heterozygous mice are born to heterozygous parent than expected (21% of the offspring are Rras2-/- and 49% of the offspring were Rras2+/-; n=378)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rras2Gt(OST361011)Lex mutation
(0 available);
any
Rras2 mutation
(31 available)
|
|
|
immune system
|
|
• B cell numbers in the spleen are reduced by about 50%
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• follicular B cell numbers are reduced by about 20%
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• marginal zone B cells are decreased by more than 50%
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• T cell numbers in the spleen are decreased about 30%
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• decrease in numbers is more evident in the memory T cell population than in controls
• decrease in memory T cells worsens with age of the mice
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• spleen weight is reduced by about 20-30%
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• spleen cellularity is reduced by about a third
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• spleen B cell follicles are smaller with fewer cells
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hematopoietic system
|
|
• B cell numbers in the spleen are reduced by about 50%
|
|
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• follicular B cell numbers are reduced by about 20%
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• marginal zone B cells are decreased by more than 50%
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• T cell numbers in the spleen are decreased about 30%
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• decrease in numbers is more evident in the memory T cell population than in controls
• decrease in memory T cells worsens with age of the mice
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• spleen weight is reduced by about 20-30%
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• spleen cellularity is reduced by about a third
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• spleen B cell follicles are smaller with fewer cells
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cellular
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• fewer homozygous and heterozygous mice are born to heterozygous parent than expected (21% of the offspring are Rras2 -/- and 49% of the offspring were Rras2 +/-; n=378)
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Analysis Tools