Analysis Tools
endocrine/exocrine glands
| N |
• mice exhibit normal glucose tolerance and show no detectable differences in pancreatic beta cell mass or size relative controls
|
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• in a splenocyte islet co-culture model, mutant islets fail to show stimulation-dependent induction of BAX conformational change, unlike wild-type islets
• in a similar co-culture model, mutant islets display resistance to cytokine-induced pancreatic beta cell death, as determined by quantification of TUNEL+ cells
|
cellular
|
• in a splenocyte islet co-culture model, mutant islets fail to show stimulation-dependent induction of BAX conformational change, unlike wild-type islets
• in a similar co-culture model, mutant islets display resistance to cytokine-induced pancreatic beta cell death, as determined by quantification of TUNEL+ cells
|
mortality/aging
| N |
• mice are viable
|
growth/size/body
| N |
• mice show normal growth and weight relative to wild-type controls
|
reproductive system
| N |
• mice breed in normal Mendelian ratios
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