All Phenotypes Slc5a1<Gt(OST315271)Lex> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex}	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5487581
cx2	Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex} Slc5a2^tm1Lex/Slc5a2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5487583

Allelic Composition	Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex}
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc5a1^{Gt(OST315271)Lex} mutation (1 available); any Slc5a1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:195941 )

• in mice fed a glucose-containing high fat diet

homeostasis/metabolism

abnormal glucose homeostasis ( J:195941 )

• following an oral glucose challenge, mice fed a glucose-free high fat diet exhibit increased intestinal glucose compared with wild-type mice

• however, mice fed a glucose-free high fat diet and treated with streptozotocin exhibit normal increase in blood glucose

abnormal circulating glucose level ( J:195941 )

• in a glucose tolerance test, mice fed a glucose-containing high fat diet exhibit no increase in circulating glucose unlike wild-type mice

decreased circulating insulin level ( J:195941 )

• in mice fed a glucose-containing high fat diet after glucose challenge

improved glucose tolerance ( J:195941 )

• whether fed standard chow or a high fat diet

• in mice fed a glucose-containing high fat diet

growth/size/body

decreased body weight ( J:195941 )

• in mice fed standard chow

slow postnatal weight gain ( J:195941 )

• in mice fed a glucose-containing high fat diet

behavior/neurological

behavior/neurological phenotype ( J:195941 )

N	• mice exhibit normal locomotor activity

decreased food intake ( J:195941 )

• in mice fed a glucose-containing high fat diet

• however, mice fed a glucose-free high fat diet exhibit normal food intake

skeleton

skeleton phenotype ( J:195941 )

N	• mice exhibit normal bone mineral density

long femur ( J:195941 )

• in female, but not male, mice at 47 weeks

increased bone trabecula number ( J:195941 )

• in the fifth lumbar vertebra spine of female, but not male, mice at 47 weeks

digestive/alimentary system

distended cecum ( J:195941 )

• cecal distention in mice fed a glucose-containing high fat diet

limbs/digits/tail

long femur ( J:195941 )

• in female, but not male, mice at 47 weeks

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:195941 )

• during an intraperitoneal glucose tolerance test in fasted mice fed a glucose-free high fat diet

• during a glomerular filtration study most of the 10 h interval of the light cycle in fed mice on a glucose-free high fat diet

decreased circulating insulin level ( J:195941 )

• during an intraperitoneal glucose tolerance test in fasted mice fed a glucose-free high fat diet

improved glucose tolerance ( J:195941 )

• during an intraperitoneal glucose tolerance test in mice fed a glucose-free high fat diet

abnormal urine homeostasis ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

• in male, but not female, mice

increased urine potassium level ( J:195941 )

• in male, but not female, mice

increased urine sodium level ( J:195941 )

• in male, but not female, mice

increased urine magnesium level ( J:195941 )

increased urine urea nitrogen level ( J:195941 )

renal/urinary system

abnormal urine homeostasis ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

• in male, but not female, mice

increased urine potassium level ( J:195941 )

• in male, but not female, mice

increased urine sodium level ( J:195941 )

• in male, but not female, mice

increased urine magnesium level ( J:195941 )

increased urine urea nitrogen level ( J:195941 )

abnormal bladder urine volume ( J:195941 )

• mice exhibit increased urine volume compared with wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:195941 )

N	• mice exhibit normal locomotor activity

increased food intake ( J:195941 )

• in male, but not female, mice

growth/size/body

decreased body weight ( J:195941 )

• in male, but not female, mice

adipose tissue

decreased total body fat amount ( J:195941 )

• in male, but not female, mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23