Phenotypes associated with this allele

• Allele Symbol: Zfp683^{Gt(OST314703)Lex}
• Allele Name: gene trap OST314703, Lexicon Genetics
• Allele ID: MGI:4276801
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp683^Gt(OST314703)Lex/Zfp683^Gt(OST314703)Lex	B6.129S5-Zfp683^Gt(OST314703)Lex	MGI:5440329

Genotype
MGI:5440329

hm1

• Allelic Composition: Zfp683^{Gt(OST314703)Lex}/Zfp683^{Gt(OST314703)Lex}
• Genetic Background: B6.129S5-Zfp683^{Gt(OST314703)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:187727 )

N • peripheral NKT cells exhibit normal cell proliferation

abnormal NK T cell morphology ( J:187727 )

• impaired Ly49C/I+ NKT cell differentiation

decreased NK T cell number ( J:187727 )

• fewer mature NKT cells at stage 3 in the thymus

• fewer NKT cells that produce IFN-gamma and IL4 or IFN-gamma alone

• fewer NKT cells expressing inhibitory Ly49 receptors

• fewer NKT cells from bone marrow cells used to reconstitute irradiated wild-type mice

• fewer peripheral NK1.1^lo NKT cells

• however, mice exhibit normal numbers of NKT cells producing IFN-gamma alone

increased interferon-gamma secretion ( J:187727 )

• in antigen activated NKT cells

• in NKT cells from mice after infection with MCMV

abnormal susceptibility to infection ( J:187727 )

• NKT cells from mice after infection with MCMV produce more interferon-gamma compared with cells from wild-type mice

• however, the clearance of MCMV infection is normal

hematopoietic system

abnormal NK T cell morphology ( J:187727 )

• impaired Ly49C/I+ NKT cell differentiation

decreased NK T cell number ( J:187727 )

• fewer mature NKT cells at stage 3 in the thymus

• fewer NKT cells that produce IFN-gamma and IL4 or IFN-gamma alone

• fewer NKT cells expressing inhibitory Ly49 receptors

• fewer NKT cells from bone marrow cells used to reconstitute irradiated wild-type mice

• fewer peripheral NK1.1^lo NKT cells

• however, mice exhibit normal numbers of NKT cells producing IFN-gamma alone