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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pi16Gt(OST292194)Lex
gene trap OST292194, Lexicon Genetics
MGI:4267708
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pi16Gt(OST292194)Lex/Pi16Gt(OST292194)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:5494664


Genotype
MGI:5494664
hm1
Allelic
Composition		 Pi16Gt(OST292194)Lex/Pi16Gt(OST292194)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi16Gt(OST292194)Lex mutation (1 available); any Pi16 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased regulatory T cell number ( J:94077 )
• increased percentage of CD25+ cells in lymph node
abnormal spleen germinal center morphology ( J:94077 )
• B cell compartment differences

immune system
increased regulatory T cell number ( J:94077 )
• increased percentage of CD25+ cells in lymph node
abnormal spleen germinal center morphology ( J:94077 )
• B cell compartment differences
abnormal lymph node B cell domain morphology ( J:94077 )
• B cell compartment differences

skeleton
abnormal bone marrow morphology ( J:94077 )
• B cell compartment differences




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory