Phenotypes associated with this allele

• Allele Symbol: Dusp14^{Gt(OST210117)Lex}
• Allele Name: gene trap OST210117, Lexicon Genetics
• Allele ID: MGI:4233674
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp14^Gt(OST210117)Lex/Dusp14^Gt(OST210117)Lex	B6.129S5-Dusp14^Gt(OST210117)Lex	MGI:6286391

Genotype
MGI:6286391

hm1

• Allelic Composition: Dusp14^{Gt(OST210117)Lex}/Dusp14^{Gt(OST210117)Lex}
• Genetic Background: B6.129S5-Dusp14^{Gt(OST210117)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:209403 )

N • normal development of CD4- CD8- double-negative, CD4+ CD8+ double-positive, and CD4+ and CD8+ single-positive thymocytes

N • normal expression pattern of CD44 and CD25 on CD4- CD8+ double-negative thymocytes

N • normal numbers of CD3+, CD4+ and CD8+ T cells, and B220+ B cells in spleen and lymph nodes

N • normal numbers of naive (CD44- CD62L+), effector memory (CD44+ CD62L-), and memory (CD44+ CD62L+) T cells in spleen

N • normal numbers of regulatory T cells (CD4+ Foxp3+) in thymus, spleen, and lymph nodes

N • normal level of anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes in vivo

N • normal level of anti-CD3- or anti-Fas-induced apoptosis of T cells in vitro

increased T-helper 1 cell number ( J:209403 )

• increased Th1 differentiation of T cells in vitro

increased T-helper 17 cell number ( J:209403 )

• increased Th17 differentiation of T cells in vitro

abnormal T cell activation ( J:209403 )

• increased number of activated CD69+ and CD25+ T cells after anti-CD3 stimulation

increased T cell proliferation ( J:209403 )

• increased T cell proliferation after anti-CD3 stimulation, anti-CD3-anti plus CD28 co-stimulation, and PMA plus ionomycin induction in vitro

• increased T cell proliferation after in vitro KLH re-stimulation of lymph nodes isolated from KLH-immunized mice

abnormal humoral immune response ( J:209403 )

• increased levels of KLH-specific IgM, IgG1 and IgG2b in serum of immunized mice

abnormal cytokine secretion ( J:209403 )

• increased Il2, Il4 and Ifng production in nave T cells after anti-CD3 stimulation, anti-CD3 plus anti-CD28 co-stimulation in vitro, and PMA plus ionomycin induction in vitro

• increased T cell cytokine production after in vitro KLH re-stimulation of lymph nodes isolated from KLH-immunized mice

• increased serum Il17a and Ifng levels after MOG-in-CFA-induced experimental autoimmune encephalomyelitis (EAE) and production in T cells after in vitro MOG-re-stimulation of lymph nodes isolated from those mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:209403 )

• severe paralysis of fore- and hindlimbs after MOG-in-CFA-induced EAE

hematopoietic system

hematopoietic system phenotype ( J:209403 )

N • normal development of CD4- CD8- double-negative, CD4+ CD8+ double-positive, and CD4+ and CD8+ single-positive thymocytes

N • normal expression pattern of CD44 and CD25 on CD4- CD8+ double-negative thymocytes

N • normal numbers of CD3+, CD4+ and CD8+ T cells, and B220+ B cells in spleen and lymph nodes

N • normal numbers of naive (CD44- CD62L+), effector memory (CD44+ CD62L-), and memory (CD44+ CD62L+) T cells in spleen

N • normal numbers of regulatory T cells (CD4+ Foxp3+) in thymus, spleen, and lymph nodes

N • normal level of anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes in vivo

N • normal level of anti-CD3- or anti-Fas-induced apoptosis of T cells in vitro

increased T-helper 1 cell number ( J:209403 )

• increased Th1 differentiation of T cells in vitro

increased T-helper 17 cell number ( J:209403 )

• increased Th17 differentiation of T cells in vitro

abnormal T cell activation ( J:209403 )

• increased number of activated CD69+ and CD25+ T cells after anti-CD3 stimulation

increased T cell proliferation ( J:209403 )

• increased T cell proliferation after anti-CD3 stimulation, anti-CD3-anti plus CD28 co-stimulation, and PMA plus ionomycin induction in vitro

• increased T cell proliferation after in vitro KLH re-stimulation of lymph nodes isolated from KLH-immunized mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:209403 )

N • normal development of CD4- CD8- double-negative, CD4+ CD8+ double-positive, and CD4+ and CD8+ single-positive thymocytes

N • normal expression pattern of CD44 and CD25 on CD4- CD8+ double-negative thymocytes

N • normal thymic cellularity

N • normal numbers of CD3+, CD4+ and CD8+ T cells, and B220+ B cells in spleen and lymph nodes

N • normal numbers of naive (CD44- CD62L+), effector memory (CD44+ CD62L-), and memory (CD44+ CD62L+) T cells in spleen

N • normal numbers of regulatory T cells (CD4+ Foxp3+) in thymus, spleen, and lymph nodes

N • normal level of anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes in vivo

N • normal level of anti-CD3- or anti-Fas-induced apoptosis of T cells in vitro

cellular

increased T cell proliferation ( J:209403 )

• increased T cell proliferation after anti-CD3 stimulation, anti-CD3-anti plus CD28 co-stimulation, and PMA plus ionomycin induction in vitro

• increased T cell proliferation after in vitro KLH re-stimulation of lymph nodes isolated from KLH-immunized mice

embryo

embryo phenotype ( J:209403 )

N • mice born at expected Mendelian ratio

growth/size/body

growth/size/body region phenotype ( J:209403 )

N • mice develop without any obvious physical abnormalities