Phenotypes associated with this allele

• Allele Symbol: Ppp1r2^{Gt(OST190571)Lex}
• Allele Name: gene trap OST190571, Lexicon Genetics
• Allele ID: MGI:4223448
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r2^Gt(OST190571)Lex/Ppp1r2^Gt(OST190571)Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:5907028
ht2	Ppp1r2^Gt(OST190571)Lex/Ppp1r2^+	B6N.129S5-Ppp1r2^Gt(OST190571)Lex	MGI:5907030

Genotype
MGI:5907028

hm1

• Allelic Composition: Ppp1r2^{Gt(OST190571)Lex}/Ppp1r2^{Gt(OST190571)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:227697 )

• die around E13.5

Genotype
MGI:5907030

ht2

• Allelic Composition: Ppp1r2^{Gt(OST190571)Lex}/Ppp1r2⁺
• Genetic Background: B6N.129S5-Ppp1r2^{Gt(OST190571)Lex}

behavior/neurological

behavior/neurological phenotype ( J:227697 )

N • no significant differences in motor activity in an open field test

enhanced contextual conditioning behavior ( J:227697 )

• increase in freezing at 24h after training in a contextual fear conditioning test suggesting improved memory retention

abnormal response to novel object ( J:227697 )

• increase in novel object recognition at 24 and 48h after training compared to wild-type controls in a novel object recognition test suggesting improved memory retention