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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndufa5Gt(RRK279)Byg
gene trap RRK279, BayGenomics
MGI:4130259
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ndufa5Gt(RRK279)Byg/Ndufa5Gt(RRK279)Byg involves: 129P2/OlaHsd MGI:5563769
cn2
 		Ndufa5Gt(RRK279)Byg/Ndufa5Gt(RRK279)Byg
Tg(Camk2a-cre)#Szi/0
Tg(Gt(ROSA)26Sor-Ndufa5)#Ctm/0 		involves: 129P2/OlaHsd * C57BL/6J * CBA * SJL MGI:5563770


Genotype
MGI:5563769
hm1
Allelic
Composition		 Ndufa5Gt(RRK279)Byg/Ndufa5Gt(RRK279)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa5Gt(RRK279)Byg mutation (0 available); any Ndufa5 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5563770
cn2
Allelic
Composition		 Ndufa5Gt(RRK279)Byg/Ndufa5Gt(RRK279)Byg
Tg(Camk2a-cre)#Szi/0
Tg(Gt(ROSA)26Sor-Ndufa5)#Ctm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa5Gt(RRK279)Byg mutation (0 available); any Ndufa5 mutation (13 available)
Tg(Camk2a-cre)#Szi mutation (0 available)
Tg(Gt(ROSA)26Sor-Ndufa5)#Ctm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
lethargy ( J:206222 )
• at 10 to 11 months
limb grasping ( J:206222 )
• at 10 to 11 months
impaired coordination ( J:206222 )
• at 10 to 11 months, mice exhibit longer latency in a pole descent test and reduced motor coordination in the grid and beam-walking tests compared with control mice

cellular
abnormal respiratory electron transport chain ( J:206222 )
• mice exhibit complex I deficiency in the cortex compared with wild-type mice

nervous system
nervous system phenotype ( J:206222 )
N
• at 11 months, cortex morphology is normal without oxidative damage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory