Phenotypes associated with this allele

• Allele Symbol: Fnip1^{Gt(RRM154)Byg}
• Allele Name: gene trap RRM154, BayGenomics
• Allele ID: MGI:4130078
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fnip1^Gt(RRM154)Byg/Fnip1^Gt(RRM154)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5445160
cx2	Fnip1^Gt(RRM154)Byg/Fnip1^Gt(RRM154)Byg Tg(BCL2)22Wehi/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5445164
cx3	Fnip1^Gt(RRM154)Byg/Fnip1^Gt(RRM154)Byg Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5445166
cx4	Fnip1^Gt(RRM154)Byg/Fnip1^Gt(RRM154)Byg Igh^tm2Cgn/Igh^tm2Cgn	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5445168

Genotype
MGI:5445160

hm1

• Allelic Composition: Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:189078 )

increased pro-B cell number ( J:189078 )

• 2- to 3-fold

• accumulation of fraction C and C'

arrested B cell differentiation ( J:189078 )

• cell intrinsic block in B cell development at the pro-B cell fractions C-C'

• not rescued by rapamycin treatment or pre-recombined B cell receptor

decreased B cell number ( J:189078 )

• severe, nearly complete absence of conventional CD19+ cells

decreased transitional stage B cell number ( J:189078 )

decreased mature B cell number ( J:189078 )

• in bone marrow

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

decreased pre-B cell number ( J:189078 )

small spleen ( J:189078 )

renal/urinary system

renal/urinary system phenotype ( J:189078 )

N • mice do not develop kidney cysts or renal failure

cellular

increased B cell apoptosis ( J:189078 )

hematopoietic system

increased B cell apoptosis ( J:189078 )

increased pro-B cell number ( J:189078 )

• 2- to 3-fold

• accumulation of fraction C and C'

arrested B cell differentiation ( J:189078 )

• cell intrinsic block in B cell development at the pro-B cell fractions C-C'

• not rescued by rapamycin treatment or pre-recombined B cell receptor

decreased B cell number ( J:189078 )

• severe, nearly complete absence of conventional CD19+ cells

decreased transitional stage B cell number ( J:189078 )

decreased mature B cell number ( J:189078 )

• in bone marrow

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

decreased pre-B cell number ( J:189078 )

small spleen ( J:189078 )

Genotype
MGI:5445164

cx2

• Allelic Composition: Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg}; Tg(BCL2)22Wehi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

hematopoietic system

increased B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

immune system

increased B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

Genotype
MGI:5445166

cx3

• Allelic Composition: Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg}; Tg(IghelMD4)4Ccg/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

immune system

increased immature B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

hematopoietic system

increased immature B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

Genotype
MGI:5445168

cx4

• Allelic Composition: Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg}; Igh^tm2Cgn/Igh^tm2Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

hematopoietic system

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

immune system

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells