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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		NlkGt(RRJ297)Byg
gene trap RRJ297, BayGenomics
MGI:4130034
Summary 4 genotypes


Genotype
MGI:5521730
ht1
Allelic
Composition		 NlkGt(RRJ297)Byg/Nlk+
Genetic
Background		 B6.129P2-NlkGt(RRJ297)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NlkGt(RRJ297)Byg mutation (0 available); any Nlk mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:198661 )
• on a rotarod
• however, mice exhibit normal performance on a dowel rod walking test




Genotype
MGI:5521738
ht2
Allelic
Composition		 NlkGt(RRJ297)Byg/NlkGt(XN619)Byg
Genetic
Background		 129S6.129P2-NlkGt(RRJ297)Byg/NlkGt(XN619)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NlkGt(RRJ297)Byg mutation (0 available); any Nlk mutation (46 available)
NlkGt(XN619)Byg mutation (0 available); any Nlk mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198661 )
• Background Sensitivity: mice on a congenic 129S6 background survive up to several months of age unlike mice on a congenic C57BL/6 background that die at birth

behavior/neurological
abnormal behavior ( J:198661 )
• various unspecified neurological and non-neurological abnormalities




Genotype
MGI:5521735
ht3
Allelic
Composition		 NlkGt(RRJ297)Byg/NlkGt(XN619)Byg
Genetic
Background		 B6.129P2-NlkGt(RRJ297)Byg/NlkGt(XN619)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NlkGt(RRJ297)Byg mutation (0 available); any Nlk mutation (46 available)
NlkGt(XN619)Byg mutation (0 available); any Nlk mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:198661 )
• Background Sensitivity: mice on a congenic C57BL/6 background die at birth unlike mice on a congenic 129S6 background that survive several months




Genotype
MGI:5521733
cx4
Allelic
Composition		 Atxn1tm1Hzo/Atxn1+
NlkGt(RRJ297)Byg/Nlk+
Genetic
Background		 B6.129-NlkGt(RRJ297)Byg Atxn1tm1Hzo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn1tm1Hzo mutation (1 available); any Atxn1 mutation (50 available)
NlkGt(RRJ297)Byg mutation (0 available); any Nlk mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:198661 )
N
• unlike Atxn1tm1Hzo heterozygotes, mice exhibit normal performance on a dowel rod walking test

nervous system
nervous system phenotype ( J:198661 )
N
• mice exhibit improved complexity of fine dendritic arbors and Purkinje cell soma at 38 to 39 weeks of age and molecular layer thickness compared with Atxn1tm1Hzo heterozygotes




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory