Phenotypes associated with this allele

• Allele Symbol: Phip^{Gt(RRJ571)Byg}
• Allele Name: gene trap RRJ571, BayGenomics
• Allele ID: MGI:4129907
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phip^Gt(RRJ571)Byg/Phip^Gt(RRJ571)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:4834276

Genotype
MGI:4834276

hm1

• Allelic Composition: Phip^{Gt(RRJ571)Byg}/Phip^{Gt(RRJ571)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164354 )

• no mice are present at 6 weeks

postnatal lethality, incomplete penetrance ( J:164354 )

• while born in normal Mendelian ratios, fewer than expected mice are present at weaning

homeostasis/metabolism

hypoglycemia ( J:164354 )

• beginning at P5 and progressing with age

increased insulin sensitivity ( J:164354 )

• mice exhibit increased insulin sensitivity compared with wild-type mice

• however, glucose tolerance and insulin serum levels are normal

cellular

abnormal cell physiology ( J:164354 )

• mouse embryonic fibroblast (MEF) exhibit decreased cell growth compared with wild-type cells

• however, MEFs exhibit increased proliferation in response to IGF-1

growth/size/body

decreased body size ( J:164354 )

• beginning at 1 week of age and progressing with age

adipose tissue

decreased total body fat amount ( J:164354 )

• relative to body weight

cardiovascular system

decreased myocardial fiber size ( J:164354 )

liver/biliary system

abnormal hepatocyte morphology ( J:164354 )

• small in size

respiratory system

abnormal lung epithelium morphology ( J:164354 )

• lung epithelium is poorly developed with severely dilated airways and fewer red blood cells compared to in wild-type mice

muscle

decreased myocardial fiber size ( J:164354 )