Phenotypes associated with this allele

• Allele Symbol: Phf20^Gt(XN131)Byg
• Allele Name: gene trap XN131, BayGenomics
• Allele ID: MGI:4129686
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phf20^Gt(XN131)Byg/Phf20^Gt(XN131)Byg	involves: 129P2/OlaHsd	MGI:5708600

Genotype
MGI:5708600

hm1

• Allelic Composition: Phf20^Gt(XN131)Byg/Phf20^Gt(XN131)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:228714 )

• while born alive, nearly all mice die within the first day of life

hematopoietic system

abnormal hematopoietic system morphology/development ( J:228714 )

• early defect

small thymus ( J:228714 )

• at E18.5 and P25

thymus hypoplasia ( J:228714 )

decreased thymocyte number ( J:228714 )

abnormal T cell differentiation ( J:228714 )

increased double-negative T cell number ( J:228714 )

decreased double-positive T cell number ( J:228714 )

decreased bone marrow cell number ( J:228714 )

• at P25

intermingled spleen red and white pulp ( J:228714 )

small spleen ( J:228714 )

• at E18.5 and P25

growth/size/body

decreased body size ( J:228714 )

• at P25

decreased body weight ( J:228714 )

• 50% of wild-type

decreased fetal size ( J:228714 )

• at E18.5

skeleton

decreased lumbar vertebrae number ( J:228714 )

• from 6 to 5 vertebra in newborn mice

delayed bone ossification ( J:228714 )

fragile skeleton ( J:228714 )

adipose tissue

decreased total body fat amount ( J:228714 )

endocrine/exocrine glands

small thymus ( J:228714 )

• at E18.5 and P25

thymus hypoplasia ( J:228714 )

decreased thymocyte number ( J:228714 )

immune system

small thymus ( J:228714 )

• at E18.5 and P25

thymus hypoplasia ( J:228714 )

decreased thymocyte number ( J:228714 )

abnormal T cell differentiation ( J:228714 )

increased double-negative T cell number ( J:228714 )

decreased double-positive T cell number ( J:228714 )

intermingled spleen red and white pulp ( J:228714 )

small spleen ( J:228714 )

• at E18.5 and P25