Phenotypes associated with this allele

• Allele Symbol: Ube3b^{Gt(RRJ142)Byg}
• Allele Name: gene trap RRJ142, BayGenomics
• Allele ID: MGI:4129255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube3b^Gt(RRJ142)Byg/Ube3b^Gt(RRJ142)Byg	involves: 129P2/OlaHsd * CBA/Ca	MGI:5529079

Genotype
MGI:5529079

hm1

• Allelic Composition: Ube3b^{Gt(RRJ142)Byg}/Ube3b^{Gt(RRJ142)Byg}
• Genetic Background: involves: 129P2/OlaHsd * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:203652 )

• fewer than expected mice are present at 2 weeks

reproductive system

reduced fertility ( J:203652 )

nervous system

nervous system phenotype ( J:203652 )

N • mice exhibit normal brain morphology

decreased brain size ( J:203652 )

decreased dentate gyrus size ( J:203652 )

small hippocampus ( J:203652 )

vision/eye

eye inflammation ( J:203652 )

• acute

calcified retina ( J:203652 )

homeostasis/metabolism

decreased circulating cholesterol level ( J:203652 )

• total cholesterol and lathosterol

decreased circulating LDL cholesterol level ( J:203652 )

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:203652 )

N • mice exhibit normal gross inner ear morphology, normal organ of Corti and no middle ear inflammation

impaired hearing ( J:203652 )

• mild

behavior/neurological

decreased grip strength ( J:203652 )

growth/size/body

decreased body size ( J:203652 )

decreased body weight ( J:203652 )

• severely

immune system

lymphangiectasis ( J:203652 )

• in the cornea

eye inflammation ( J:203652 )

• acute