Phenotypes associated with this allele

• Allele Symbol: Cops6^{Gt(RRI087)Byg}
• Allele Name: gene trap RRI087, BayGenomics
• Allele ID: MGI:4128701
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cops6^Gt(RRI087)Byg/Cops6^Gt(RRI087)Byg	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5003351
hm2	Cops6^Gt(RRI087)Byg/Cops6^Gt(RRI087)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5003350
ht3	Cops6^Gt(RRI087)Byg/Cops6^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5003352
cx4	Cops6^Gt(RRI087)Byg/Cops6^Gt(RRI087)Byg Trp53^tm1Glo/Trp53^tm1Glo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5003353
cx5	Cops6^Gt(RRI087)Byg/Cops6^+ Trp53^tm1Glo/Trp53^+	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5003356

Genotype
MGI:5003351

hm1

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg}
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:172038 )

• no mice are detected at E9.5

Genotype
MGI:5003350

hm2

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} mice die by E8.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:172038 )

• no mice are detected at E10.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:172038 )

• while Mendelian ratios are present at E7.5, fewer than expected mice are present at E8.5 and E9.5

Genotype
MGI:5003352

ht3

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Increase in gamma-irradiation-induced apoptosis in Cops6^{Gt(RRI087)Byg}/Cops6⁺ thymus and developing central nervous system

mortality/aging

increased mortality induced by gamma-irradiation ( J:172038 )

cellular

increased sensitivity to induced cell death ( J:172038 )

• mouse embryonic fibroblasts exhibit increased sensitivity to doxorubicin-induced apoptosis compared with wild-type cells

increased cellular sensitivity to gamma-irradiation ( J:172038 )

• in mouse embryonic fibroblasts

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

neoplasm

decreased incidence of tumors by ionizing radiation induction ( J:172038 )

• mice exhibit a reduced incidence of gamma-irradiation-induced tumors compared with wild-type mice

immune system

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

hematopoietic system

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:172038 )

endocrine/exocrine glands

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

Genotype
MGI:5003353

cx4

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg}; Trp53^tm1Glo/Trp53^tm1Glo
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

The embryonic lethality of Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} mice can be partially rescued by concomitant loss of Trp53

mortality/aging

prenatal lethality, complete penetrance ( J:172038 )

• no mice are detected at birth

• however, mice were identified at E8.5 to E10.5 indicating a partial rescue

embryo

embryonic growth retardation ( J:172038 )

• at E9.5

decreased embryo size ( J:172038 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:172038 )

• at E9.5

decreased embryo size ( J:172038 )

• at E9.5

Genotype
MGI:5003356

cx5

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6⁺; Trp53^tm1Glo/Trp53⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:172038 )

• mice exhibit a spectrum of gamma-irradiation-induced tumors intermediate to in Trp53^tm1Glo heterozygotes and Cops6^{Gt(RRI087)Byg} heterozygotes