Phenotypes associated with this allele

• Allele Symbol: Inpp5f^Gt(XL571)Byg
• Allele Name: gene trap XL571, BayGenomics
• Allele ID: MGI:4128518
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inpp5f^Gt(XL571)Byg/Inpp5f^Gt(XL571)Byg	involves: 129P2/OlaHsd	MGI:4946232

Genotype
MGI:4946232

hm1

• Allelic Composition: Inpp5f^Gt(XL571)Byg/Inpp5f^Gt(XL571)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:170072 )

• mice exhibit increased isoproterenol-induced cardiac hypertrophy compared with similarly treated wild-type mice

cardiac fibrosis ( J:170072 )

• in isoproterenol-treated mice

increased response of heart to induced stress ( J:170072 )

• mice exhibit increased isoproterenol-induced cardiac hypertrophy with patchy fibrosis and increased apoptosis compared with similarly treated wild-type mice

• however, untreated hearts are normal

homeostasis/metabolism

increased response of heart to induced stress ( J:170072 )

• mice exhibit increased isoproterenol-induced cardiac hypertrophy with patchy fibrosis and increased apoptosis compared with similarly treated wild-type mice

• however, untreated hearts are normal

muscle

increased cardiomyocyte apoptosis ( J:170072 )

• in isoproterenol-treated mice

cellular

increased cardiomyocyte apoptosis ( J:170072 )

• in isoproterenol-treated mice

growth/size/body

cardiac hypertrophy ( J:170072 )

• mice exhibit increased isoproterenol-induced cardiac hypertrophy compared with similarly treated wild-type mice