Phenotypes associated with this allele

• Allele Symbol: Klhl20^Gt(XF202)Byg
• Allele Name: gene trap XF202, BayGenomics
• Allele ID: MGI:4127967
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl20^Gt(XF202)Byg/Klhl20^Gt(XF202)Byg	B6.129P2-Klhl20^Gt(XF202)Byg	MGI:5490898

Genotype
MGI:5490898

hm1

• Allelic Composition: Klhl20^Gt(XF202)Byg/Klhl20^Gt(XF202)Byg
• Genetic Background: B6.129P2-Klhl20^Gt(XF202)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:196827 )

• fewer than expected mice are present at P28

vision/eye

vision/eye phenotype ( J:196827 )

N • mice exhibit normal periocular lacrimal glands and embryonic development of the eye

retina neovascularization ( J:196827 )

• cornea are highly vascularized

corneal vascularization ( J:196827 )

• cornea are highly vascularized

abnormal corneal epithelium morphology ( J:196827 )

• progressive epithelial metaplasia leading to corneal opacity

corneal epithelium hyperplasia ( J:196827 )

• hyperplasia with altered differentiation and severe keratinization

corneal opacity ( J:196827 )

• starting in the third postnatal week

cardiovascular system

retina neovascularization ( J:196827 )

• cornea are highly vascularized

corneal vascularization ( J:196827 )

• cornea are highly vascularized

homeostasis/metabolism

increased susceptibility to injury ( J:196827 )

• following mechanical injury (corneal abrasion), mice exhibit rapid development of corneal opacity with epithelial hyperplasia, stromal infiltrations and superficial keratinized cells unlike wild-type mice